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P111. Arterial stiffness in patients with inflammatory bowel diseases

L. Zanoli, M. Cannavò, P. Castellino, G. Inserra

Internal Medicine, University of Catania, Catania, Italy

Introduction: The chronic inflammation may predispose to vascular remodelling and arterial stiffness in patients with inflammatory bowel diseases (IBD).

Aim: To evaluate early alterations of arterial function in patients with IBD.

Methods: 29 young patients with IBD without the classical cardiovascular risk factors and 10 controls were enrolled in this study. SphygmoCor (AtCor Medical) was used to a non-invasively estimation of (a) arterial stiffness [carotid-femoral pulse wave velocity (cf-PWV) carotid-radial pulse wave velocity (cr-PWV) and augmentation index adjusted for heart rate (AIx)], (b) myocardial perfusion [subendocardial viability ratio (SEVR)] and (c) central systolic (central-SBP), diastolic (central-DBP), and pulse pressure (central-PP).

Results and Discussion: Main clinical data of our population are reported in table 1. In young patients with IBD, in absence of conventional cardiovascular risk factors, the arterial stiffness is increased. Patients with IBD have higher central-PP, cf-PWV, cr-PWV and AIx and reduced myocardial perfusion and central-DBP than controls. In addition, in multivariate stepwise regression analysis, the use of steroidal anti-inflammatory therapy (R2 = 0.16, beta 0.90 m/s, 95%CI 0.23–1.56 m/s, p < 0.05) and the age (1 year increase, R2 = 0.27, beta 0.08 m/s, 95%CI 0.04–0.13 m/s, p < 0.05) are positively associated with cr-PWV, an indicator of the muscular arteries stiffness.

Conclusions: Early alterations of arterial function and myocardial perfusion were found in patients with IBD in absence of conventional cardiovascular risk factors. The steroidal anti-inflammatory therapy, an indicator of the inflammatory state of the patient, was associated with the muscular arteries stiffness and explains 16% of the cr-PWV variability.

Table 1. Main clinical data of study populationa
 Controls (n = 10)IBD (n = 29)P value
Age (years)26.7±3.528.4±7.0NS
Male gender (%)60.055.2NS
Weight (kg)66.9±13.567.1±16.6NS
Height (m)1.68±0.091.67±0.10NS
Brachial SBP (mm Hg)113.5±14.9114.9±11.7NS
Brachial DBP (mm Hg)70.6±6.564.8±10.2<0.05
Brachial PP (mm Hg)42.9±13.550.1±10.1NS
Heart rate64.3±5.968.9±9.6NS
cf-PWV (m/s)5.5±0.46.5±1.3<0.001
cr-PWV (m/s)7.4±0.78.4±1.1<0.05
AIx (%)−5.8±10.86.4±10.5<0.05
Central SBP (mm Hg)97.4±9.797.8±10.5NS
Central DBP (mm Hg)71.6±6.865.7±10.50.05
Central PP (mm Hg)25.8±7.632.1±6.5<0.05
SEVR1.65±0.221.45±0.26<0.05
Steroidal anti-inflammatory therapy (%)041.3<0.001
aValues are mean±SD.