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P117. Evaluation of stress in inflammatory bowel disease patients

M. Iglesias1, M. Barreiro-de Acosta1, I. Vázquez2, M. Piñeiro1, A. Figueiras1, A. Cao1, A. Lorenzo1, J. Dominguez-Muñoz1

1University Hospital, Santiago de Compostela, Spain; 2Psychology University, Santiago de Compostela, Spain

Aim: Psychologic stress has been defined as a process in which environmental demands tax or exceed the adaptative capacity of an organism, resulting in psychological and biological changes that may place persons at risk for disease. There is a long but inconsistent history of studies about the relationship between stress and Inflammatory Bowel Disease (IBD) Aim of present study was to assess the perceived stress in patients with IBD and to determine differences between gender, clinical activity or being Crohn's disease (CD) or ulcerative colitis (UC) patients.

Methods: A prospective study with consecutive inclusion of patients was designed. CD and UC patients older than 18 years were included. Patients were stratified according to demographic parameters and clinical activity (Harvey-Bradshaw for CD or Mayo for UC). Remission was defined in CD as a Harvey-Bradshaw score ≤4 or and in UC as a Mayo score ≤2. Stress was assessed with the Perceived Stress scale Spanish version (PSS). This scale is a self-report instrument that assesses the level of perceived stress during the last month, consists of 14 items with a response format of a five-point scale (0 = never, 1 = almost never, 2 = once in when, 3 = often, 4 = very often). The sum score obtained indicates that a higher score corresponds to a higher level of perceived stress (range 0–56). Differences in stress between CD patients and UC, gender and clinical activity were analyzed with ANOVA test or Kruskal-Wallis where was appropriate.

Results: 708 consecutive patients were included; 336 (47%) male, mean age 44.62 years, range 18–86 years, 277 (39%) patients with CD and 431 (68%) with UC. The mean in the PSS was 23.47, with a standard deviation (SD) of 9.62. We did not observe differences in the PSS mean between CD patients (23.49 with a SD of 9.45) and UC patients (23.45, SD: 9.74; p = 0.936). Regarding gender women had a significant higher PSS mean (24.32, SD: 9.68) than men (22.53, SD: 9.48; p = 0.007). Stress was lower in patients in remission (22.33, SD: 9.15) than in those which had not achieved remission (24.36, SD: 9.90; p = 0.004).

Conclusions: In IBD patients perception of stress is higher in patients without remission. There were not differences in perception of stress among CD and UC patients. Perception of stress was higher in female patients.