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P122. Extraintestinal manifestations in a single centre cohort of chronic inflammatory bowel disease patients

C. Corrado, R. Pica, E. Avallone, C. Cassieri, A. De Carolis, P. Paoluzi, P. Vernia

Policlinico Umberto I, Rome, Italy

Aim: Ulcerative colitis (UC) and Crohn's disease (CD), the two main expressions of inflammatory bowel disease (IBD), may be associated with extraintestinal manifestations (EIMs). Aim of this study has been to investigate the prevalence, type and time of onset of extraintestinal manifestations in a large series of Italian IBD patients.

Materials and Methods: Eight hundred and one consecutive IBD out-patients, first referred to our centre, from 2000 to 2010 with a mean follow-up of 40.7±31.5 SD months, were retrospectively studied. Five hundred and ninety-three (74%) patients were affected by ulcerative colitis (mean age 51.5±15.5 SD years) and 208 (26%) by Crohn's disease (mean age 49±16.1 SD years). Four hundred and thirty-three (54%) were male and 368 (46%) female.

Results: EIMs were observed in 319 (39.8%) patients, 208 with UC and 111 with CD, with a prevalence of 35.1% and 53.3%, respectively. The EIMs found were: 227 arthritis (UC 27.2%, CD 31.7%), 13 ankylosing spondylitis (UC 1.3%, CD 2.4%), 24 uveitis (UC 1.7%, CD 6.7%), 7 pyoderma gangrenosum (UC 0.3%, CD 2.4%), 17 erythema nodosum (UC 1.3%, CD 4.3%), 11 psoriasis (UC 1.2%, CD 1.9%), 6 aphthous stomatitis (UC 0.5%, CD 1.4%), 5 sclerosing cholangitis (UC 0.5%, CD 1%), 9 Hashimoto's thyroiditis (UC 1%, CD 1.4%).

Thirty-six EIMs were observed before the diagnosis of IBD (mean period 4.6±3.1 SD, range 1–24 years); 221 EIMs after diagnosis (mean period 10.4±8.4 SD, range 2–44 years) and 62 were present at the time of diagnosis.

Conclusions: The prevalence of EIMs is in keeping with those reported in the literature. Musculoskeletal manifestations were the most commonly EIMs observed, confirming the need for close cooperation with rheumatologists. They were often more severe and disabling than the intestinal symptoms of IBD, thus suggesting that prime attention should be given to EIMs in order to improve Quality of Life of IBD patients.