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P125. Prevalence of metabolic syndrome in a Turkish population with inflammatory bowel disease

E. Yorulmaz1, G. Adali1, H. Yorulmaz2, G. Tasan1, C. Ulasoglu1, I. Tuncer1

1S.B. Istanbul Goztepe Eah Gastroenterology, Istanbul, Turkey; 2Halic University, Istanbul, Turkey

Aim: Metabolic syndrome (MS) is a clinical situation in which the cardiovascular risk factors are clustered and the components of MS are abdominal obesity, hypertriglyceridemia, low levels of high-density lipoprotein cholesterol (HDL-C), high blood pressure and insulin resistance. There is not enough data of the prevalence of MS in patients with inflammatory bowel disease (IBD). The aim of this study was to determine the prevalence of MS in a group of Turkish patients with IBD.

Methods: 177 patients with IBD aged 18 years and older are included. There were 62 patients with Crohn's disease (CD) (28 females, 34 males; mean age, 36.7 years) and 115 with ulcerative colitis (UC) (49 females, 66 males, mean age, 43.9 years). MS was studied using the International Diabetes Federation (IDF) criteria of which at least three criteria were sufficient. Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) was used to determine insulin resistance.

Results: Prevalence of MS was significantly higher in UC patients (29.5%) compared to CD patients (17.7%) (p < 0.01). Metabolic syndrome was found in 12 (10.3%) of 117 IBD patients younger than 45 years of age where as it was found in 33 (55%) of 60 IBD patients older then 45 (p < 0.001). No difference was observed in the prevalence of MS between male and female patients (p > 0.05). Waist circumference (WC), HOMA-IR, body mass index (BMI) (p < 0.05), systolic and diastolic blood pressure, total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels (p < 0.01) were significantly higher in UC patients than those with CD. BMI and insulin levels (p < 0.001); fasting plasma glucose, triglycerides, uric acid levels and WC (p < 0.05) were found higher in 31 (27%) insulin resistant patients (whose HOMA-IR was higher than 2.5) with UC than 84 (73%) patients without.

Conclusions: Increasing prevalence of MS with aging, in patients with IBD, particularly in those with UC suggests increased risk of cardiovascular disease and type 2 diabetes. Therefore in the follow up of these patients aged 45 and over, it is essential to evaluate MS criteria.