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P156. Quality of life, anxiety and depression in patients with inflammatory bowel diseases depend of extraintestinal manifestations

E. Bodryagina1, D. Abdulganieva1, A. Odintsova2

1Kazan State Medical University, Kazan, Russian Federation; 2Republican Clinical Hospital, Kazan, Russian Federation

Background and Aim: Inflammatory bowel diseases (IBD) are life-long suffering which leads to disability. Health related quality of patient's life (QoL) is decreased in these conditions. IBD, such as ulcerative colitis (UC) and Crohn's disease (CD) are associated with a varied extraintestinal manifestations. The aim of our work was evaluate the QOL, severity of anxiety and depression in patients with IBD depending on extraintestinal manifestations and disability.

Materials and Methods: 50 patients with IBD was prospectively enrolled into the study. We used a specialized international questionnaire to assess QOL of patients with IBD (IBDQ), 30 patients also applied Anxiety and Depression Scale (HAD). Patients with UC was 26 (52%), with CD – 24 (48%). The average age of patients at the time of the study amounted to 35.9±13.3 years. Male was 24 (48%), women was 26 (52%). 25 (50%) patients had a variety of extraintestinal manifestations of IBD, and 16 cases were arthropathies of different localization, 11 – reduce of bone mineral density, 1 – pyoderma gangrenosum, 1 – primary sclerosing cholangitis, 1 – erythema nodosum (it should be noted that in some cases, there were combinations of two or three extraintestinal manifestations in one patient). Disability patients were in 10 cases (20%).

Results: Reduced QoL was observed in all cases. According to the IBDQ mean QoL was: in patients without extraintestinal manifestations – 135.3 points, with extraintestinal manifestations – 133.2 points; patients without disability – 132.5 points, with a disability – 134.9 points (maximum value for this index – 224 points). Anxiety was significantly higher in patients with extraintestinal manifestations (68% versus 50%, OR 2.2). Depressive disorders were also higher in the group with extraintestinal manifestations (63% versus 43%, OR 2.2). The group of patients with disabilities were significantly higher as anxiety disorders (83% versus 54%, OR 4.2), and depressive disorders (67% versus 50%, OR 2.0).

Conclusion: All patients with IBD, regardless of the clinical course of disease had reduction in QOL. Physicians should be prepared for increase of anxiety and depression among patients with IBD with extraintestinal manifestations and in patients with disability, as this may affect the management of these patients.

Figure 1. Extraintestinal manifestations of IBD.