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P332. Cancer in inflammatory bowel disease 15 years after diagnosis in a population-based European collaborative follow-up study

K. Katsanos1, A. Tatsioni2, N. Pedersen3, M.N. Shuhaibar4, V. Hernández5, P. Politi6, E. Rombrechts7, M. Pierik7, J. Clofent5, M. Beltrami8, P. Bodini6, J. Freitas9, I. Mouzas10, G. Fornaciari8, B. Moum11, P.L. Lakatos12, S. Vermeire13, E. Langholz3, S. Odes14, C. O'Morain4, R. Stockbrugger7, P. Munkholm3, E.V. Tsianos1

1Department of Hepato-Gastroenterology, Ioannina, Greece; 2Department of Family Medicine, Medical School of Ioannina, Ioannina, Greece; 3Department of Gastroenterology, Herlev University Hospital, Denmark; 4Department of Gastroenterology, Adelaide & Meath Hospital, Trinity College, Dublin, Ireland; 5Department of Gastroenterology, University Hospital of Vigo, Spain; 6Department of Gastroenterology, Hospital of Cremona, Italy; 7Department of Gastroenterology, University Hospital Maastricht, The Netherlands; 8Department of Gastroenterology, Hospital Santa Maria Nuova, Reggio Emilia, Italy; 9Department of Gastroenterology, Hospital Garcia de Orta, Almada, Portugal; 10Department of Gastroenterology, University Hospital of Heraklion, Greece; 11Department of Gastroenterology, Medical Department, Aker University Hospital, Oslo, Norway; 121st Department of Medicine, Semmelweis University, Budapest, Hungary; 13Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium; 14Department of Gastroenterology, Soroka Hospital and Ben Gurion University of the Negev, Beer Sheva, Israel

Aim: To determine dysplasia and cancer in the 1993–2009 European Collaborative Inflammatory Bowel Disease (EC-IBD) Study Group cohort.

Materials and Methods: A physician per patient form was completed for 681 inflammatory bowel disease patients (445UC/246CD) from 9 centers (7 countries) derived from the original EC-IBD cohort. For the 15-year follow up period, rates of detection of intestinal cancer and dysplasia as well as extraintestinal neoplasms were computed.

Results: Patient follow-up time was fifteen years. In total 62/681 patients (9.1%) [41 with ulcerative colitis/21 with Crohn's disease, 36 males/26 females were diagnosed with sixty-six cancers (four patients with double cancers). Colorectal cancer was diagnosed in 9/681 patients [1.3%] (1 Crohn's disease and 8 ulcerative colitis patients). The remaining 53 cancers were extraintestinal. There was a trend for higher prevalence of intestinal cancer in the Northern centers compared to Southern centers [p = NS]. Southern centers had more cases of extraintestinal cancer compared to Northern centers [p = NS]. In total 17/681 patients (2.5%) had colorectal dysplasia.

Conclusion: In the fifteen-year follow up of the EC-IBD Study Group cohort the prevalence of cancer was 9.1% with most patients having a single neoplasm and an extraintestinal neoplasm. In Northern centers there was a trend for more intestinal cancers while in Southern centers there was a trend for more extraintestinal cancers compared to Northern centers.