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P336. Experimental inflammatory bowel disease registry: Incidence and prevalence in Forli' district in Italy (1993–2009)

D. Valpiani1, S. Maltoni1, I. Manzi1, O. Giuliani2, A. Colamartini2, A. De Padova1, F. Falcini2, E. Ricci1

1Ospedale Morgagni, Forli, Italy; 2Romagna Cancer Institute, Meldola, Forli, Italy

Aims: Crohn's disease (CD) and Ulcerative Colitis (UC) are inflammatory chronic bowel disease with high social economic burden. In Europe, the annual incidence rate is 4–12 cases per 100.000 persons. Large population based epidemiologic study are lacking in Italy. Our IBD UNIT, estabilished in Forlì since 2004, started an experimental project to realize a population based pathology registry. We got contribution of Romagna Cancer Record. The aims are: incidence and prevalence evaluation in Forlì district's population (178.977 inhabitants); surveillance and better planning of IBD unit activity.

Methods: From 1993 to 2009, our Registry evaluated all patients with IBD (Crohn disease CD, Ulcerative Colitis UC and inderminate colitis IC) living in Forlì. We included also IBD patients living in Forlì with diagnosis set in other Romagna Region hospitals. We obtained informations from computerized hospital database, histological and endoscopic findings, hospital discharge summaries, Romagna Cancer Record and General Practitioner database. A data manager matched all informations.

Results: We analyzed 1465 IBD cases in Forlì district. About these, 472 were excluded because no longer resident, 106 because double, 29 because not included in time interval. The final collection included 858 (461 M; 397 F) patients. The proportion during the study period was: 66% (317 M; 249 F) patients with UC, 33.1% (140 M;144 F) with CD, 0.9% (4 M; 4 F) with indeterminate colitis. Among the CD patients, 51.2% were younger than 44 years. 48.8% of all cases had diagnosis between 1993–2000. In 1993–2009 period, the average annual incidence standardized for European population rate for 100.000 was 9.2 (95% CI: 8.1–10.3) for CD and 17.2 (95% CI: 15.7–18.7) for UC. Among women with UC, we observed an incidence rate peak at 30–34 years old (specific rate 25.1). A similar trend was pointed out for men with UC (specific rate 28.3). For CD patients, we didn't observe any significant variation. For all IBD patients, the point prevalence rate for 100.000 persons on December 31, 2009 (restricted to 16 years of evaluation), was 272 for UC (95% CI 248.4–295.0) and 138.2 for CD (95% CI 121.3–155).

Conclusions: The experimental population based pathology registry is an effective tool for checking and planning IBD unit organization. Our preliminary data seem to confirm probable underestimated relevance of IBD in Italy even if they need to be validated with an adequate follow up.