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P349. Profile of Belgian pediatric Crohn's disease (CD) patients: Associations between variables at diagnosis

E. De Greef1,2, I. Hofman3, F. Smets4, S. Van Biervliet5, M. Scaillon6, B. Hauser2, I. Paquot7, P. Alliet8, W. Arts9, O. Dewit4, H. Peeters5, F. Baert10, G. D'Haens11, J.F. Rahier12, I. Etienne13, O. Bauraind14, A. Van Gossum15, S. Vermeire3, F. Fontaine16, V. Muls17, E. Louis18, F. Van de Mierop19, J.C. Coche14, J.J.M. Mahachie20, G. Veereman1,2

1Queen Paola Children's Hospital, Antwerp, Belgium; 2UZ Brussels, Brussels, Belgium; 3UZ Gasthuisberg, Leuven, Belgium; 4UCL St Luc, Brussels, Belgium; 5UZ Gent, Gent, Belgium; 6Hôpital des enfants Reine Fabiola, Brussels, Belgium; 7CHC Clinique de l'Esperance, Liège, Belgium; 8Jessa Hospital, Hasselt, Belgium; 9ZOL, Genk, Belgium; 10H Hart Hospital, Roesselare, Belgium; 11Imelda Hospital, Bonheiden, Belgium; 12UCL, Mont Godinne, Belgium; 13CHR de la Citadelle, Liège, Belgium; 14Clinique St Pierre, Ottignies, Belgium; 15ULB Erasme, Brussels, Belgium; 16CHU St Joseph, Liège, Belgium; 17CHU St Pierre, Brussels, Belgium; 18CHU Sart Tilman, Liège, Belgium; 19St Augustinus Hospital, Antwerp, Belgium; 20Montefiore Institute, ULG, Liège, Belgium

Objective: In addition to describing disease phenotype, the aim of the Belgian Registry for pediatric Crohn's Disease (BELCRO) was to determine associations between variables at diagnosis.

Methods: Previously and newly diagnosed CD patients under 18 yrs were recruited over a 2 y period (May 1, 2008 – April 30, 2010) from 22 Belgian pediatric and adult centers after obtaining informed consent as well as assents. Demographic and descriptive data were recorded. Non-parametric association tests were used to investigate relationships between variables of interest at diagnosis.

Results: Neonatal parameters of birth weight, gestational age and mode of delivery reveal no associations with age, disease location or disease severity at diagnosis. However, a positive association between duration of breastfeeding – age at diagnosis (p = 0.0003) and duration of breastfeeding – disease location (L2) (p = 0.015) is established. No correlations are found between medical antecedents (antibiotic use, major stressful events 3 months prior to diagnosis, surgery) and disease onset, location or severity at diagnosis. Only patients who suffered an infectious episode 3 months prior to diagnosis are significantly younger at diagnosis (p = 0.013). Younger age at diagnosis is positively correlated with familial IBD (p = 0.03) but disease severity, disease location and age at diagnosis are not associated with a family history of other auto-immune diseases. Growth (z-scores for height) and PCDAI are associated (p = 0.004). PCDAI is significantly higher in ileal disease (L1) (p = 0.013) and ileocolonic disease (L3) (p = 0.011) while no association between disease location and age at diagnosis is present.

Conclusion: Data from the BELCRO at diagnosis indicate that the younger patients are more likely to have a positive familial history for IBD, to have have been breastfed and to have experienced an infectious episode prior to diagnosis. Patients with higher PCDAI scores at diagnosis are more likely to present with ileal or ileo-colonic disease and growth delay.