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P357. Clinical epidemiology of inflammatory bowel disease in a Libyan population

A.I. Shaban, M. Gabr, A. Burwaiss, A. Bani, S. Sannuk, M. Al-Naagi, M. Fathi, N. Hmeda, A.F. Bisheya, E. Shaban

Tripoli Medical Center, Tripoli, Libyan Arab Jamahiriya

Aim: To study the descriptive epidemiology and clinical profile of patients with inflammatory bowel disease.

Method and Material: Design: Retrospective study.

Setting: Regional hospital, Tripoli.

Patients: Patients with inflammatory Bowel Disease diagnosed between September 1991 and September 2010.

Results: Over the period studied, 319 patients (197 patients had ulcerative colitis, 112 patients had Crohn's disease and 10 patients had undetermined inflammatory bowel disease) were diagnosed with inflammatory bowel disease. Our hospital-based incidence and prevalence rates of ulcerative colitis had increased 3.75- and 3.98-folds, respectively over that period while incidence and prevalence rates of Cohn's disease had increased 4.1- and 3.4-folds, respectively over the same period. The mean age at diagnosis was 33.1 years and the median duration of disease was 64 months. 7.4% of patients had a first degree relative with inflammatory bowel disease.

For ulcerative colitis patients most patients had distal disease (45%) followed by left colonic disease (29%) and pancolitis (26%). For Crohn's disease patients most patients had ileocolonic disease (58.9%) followed by Crohn's colitis (19.6%) and ileal disease (17.9%), 3.6% of patients had isolated upper disease; more patients had stricturing (42.9%) than non-stricturing and non-penetrating disease (33%) and penetrating disease (24.1%). Perianal fistula occurred in 11.6% of patients. At diagnosis, most of the ulcerative colitis and Crohn's disease patients (81% and 66.1% respectively) had mild to moderate disease. At the time of this study, 63.6% of the patients were in disease remission with medical treatment. However, 63.5 patients had undergone surgery for diagnosis or complication. One patient had developed colorectal cancer.

Conclusion: The incidence and prevalence of IBD in this cohort of a Libyan population falls in the intermediate range of that reported for white populations in Europe, North America and Asia. The incidence and prevalence of inflammatory bowel disease are increasing in the Libyan population. It usually affects young persons with smaller proportion of patients presented with severe disease. More epidemiological and clinical studies are needed for this emerging disease in Libya.

Keywords: Inflammatory bowel disease, incidence, prevalence, Epidemiology.