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P089. Patients' knowledge of pregnancy-related issues in women with inflammatory bowel disease and validation of a novel assessment tool (‘CCPKnow’)


C. Selinger1, J. Eaden2, J. McLaughlin1, R. Leong3, S. Lal1

1Salford Royal Hospital, Gastroenterology, Salford, United Kingdom; 2University Hospitals of Coventry and Warwickshire, Gastroenterology, United Kingdom; 3Concord Hospital, Sydney, Australia



Background: Inflammatory bowel diseases (IBD) often affect women of childbearing age and complex treatment decisions are often needed. Little is known how much women with IBD know about this difficult area. This study aimed to develop a novel tool (‘CCPKnow’) to assess patient knowledge of pregnancy-related issues in IBD and to describe it in a cohort of women with IBD.

Methods: ‘CCPKnow’ was developed using feedback from a focus group. Discriminate ability was validated by 4 groups with different backgrounds of IBD knowledge. Internal consistency, readability and receiver operator characteristics (ROC) curves were also calculated. The tool was then used on a cohort of 145 women with IBD (65 UC, 65 CD, 15 IND) aged 18–45 years. Construct validity was assessed against ‘CCKnow’, a validated tool to assess patients' general knowledge of IBD. Factors associated with differences in CCPKnow were determined.

Results: Median CCPKnow scores were significantly different between the four validation groups (5.5/9/10/16), p < 0.001). Internal consistency was demonstrated by Cronbach alpha of 0.94. Readability analysis showed a Flesch-Kincaid Grade Level of 3.6 (= reading age of 9 years). The ROC had an area under the curve of 0.973 demonstrating excellent ability to discriminate different levels of knowledge. Correlation with CCKnow revealed a Spearman's rho of 0.61 (P < 0.001). 44.8% of women had poor, 27.6% adequate, 17.3% good, and 10.3% very good knowledge. Better knowledge was associated with Caucasian ethnicity (P = 0.008), household income >EUR61.500 (P = 0.006), having a partner (P = 0.03), having had children since IBD diagnosis (P = 0.04), Crohn's and Colitis Australia membership (P > 0.001), longer disease duration (P = 0.001), and a diagnosis of Crohn's disease (P > 0.001).

Conclusions: CCPKnow is the first tool to assess knowledge of pregnancy-related issues in IBD. The tool demonstrated excellent test characteristics (internal consistency, ROC, readability) and the ability to discriminate between different levels of knowledge. Knowledge of pregnancy-related issues in IBD (CCPKnow) is closely related to general knowledge of IBD (CCKnow). Nearly half of women with IBD had poor knowledge of IBD, indicating a need for more information and better education.