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P104. Correlation between serological biomarkers and endoscopic activity in patients with inflammatory bowel disease (IBD)


P. Miranda-García1, M. Chaparro2, J.P. Gisbert2

1Hospital De La Princesa, Madrid, Spain; 2Hospital De La Princesa, IP, Gastroenterology and CIBEREHD, Madrid, Spain



Background: The correlation between serological biomarkers and endoscopic activity has not been well established.

Objectives: To evaluate the correlation between serological biomarkers and endoscopic activity in IBD. To identify the serological biomarkers with the best accuracy to assess the endoscopic activity in patients with IBD.

Methods: Patients who underwent an ileocolonoscopy between January 2010 and June 2011 were included. Blood samples were obtained from each patient determining haematological parameters, C‑reactive protein (CRP), orosomucoid, erythrocyte sedimentation rate (ESR) and fibrinogen. Patients with ileal disease who had neither ileoscopy nor magnetic resonance enterography (MRE) were excluded. The endoscopic activity was classified based on the Endoscopic Ulcerative Colitis Activity Index (UC-DAI) (endoscopic activity: UC‑DAI ≥2) in the case of ulcerative colitis (UC) and based on the endoscopist criteria in Crohn's disease (CD) patients. MRE activity was determined by the radiologist criteria. The accuracy of each biomarker was assessed by the area under the ROC curve (AUC). The best cut-off value for each biomarker was identified; for it, sensitivity (Se), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV) were calculated.

Results: Eighty patients were included. The median age was 49 years, 51% were female, 54% had CD. The accuracy for CD and UC of the best serological biomarkers is shown in the tables. Table 2 shows the subanalysis in patients with post-surgical recurrence.

Table 1. CD: Patinets without surgical resection
BIOMARKERAUCBEST CUT-OFF VALUESe (%)Sp (%)PPV (%)NPV (%)
Orosomucoid0.85111.9 mg/dl5710010043
Fibrinogen0.81475 mg/dl6510010046
Platelets0.80341,000/ml3810010035
CRP0.781.1 mg/l3810010035
Neutrophils0.784,780/ml3810010035
Table 2. UC
BIOMARKERAUCBEST CUT-OFF VALUESe (%)Sp (%)PPV (%)NPV (%)
ESR0.701952797852
Haemoglobin0.6510.5 g/dl810010040
Leukocytes0.617,390/ml39797544
Platelets0.60416,000/ml810010046

Conclusions: Serological biomarkers have good accuracy in the diagnosis of inflammatory activity in CD patients without surgical resection. They are much less useful for the detection of postsurgical recurrences. The accuracy of these markers is, in general, worse in UC than in CD.