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P117. Influence of anaemia on health related quality of life in inflammatory bowel disease patients


R. Ferreiro1, M. Iglesias1, M. Barreiro-de Acosta1, A. Lorenzo Gonzalez1, J.E. Domíngez-Muñoz1

1University Hospital, Santiago De Compostela, Spain



Background: Anaemia is a relevant and frequent condition in patients with inflammatory bowel disease (IBD), which may affect their quality of life (HRQOL). The aim of this study was to evaluate if the presence of anaemia was associated with a worse HRQOL in IBD patients.

Methods: A cross-sectional, prospective study with consecutive patient recruitment was designed. All adult patients with IBD who attend the IBD Unit were included. Anaemia was defined as hemoglobin levels above 12 g/dl in females and 13 g/dl in males according to the World Health Organization (WHO). Remission was defined as a Harvey score ≤4 in Crohn's disease (CD) and a Mayo score ≤2 in Ulcerative Colitis (UC) respectively. To asses quality of life we used in all patients the IBDQ-36 and SF-36 questionnaires. IBDQ-36 is a questionnaire with 5 dimensions (Bowel Symtoms, Systemic Symptoms, Functional Impairment, Social Impairment, and Emotional Function). The SF-36 includes 8 scales (Physical Functioning, Role-Physical, Bodily Pain, General Health, Vitality, Social Functioning, Role-Emotional and Mental Health). Results are shown as mean and standard deviation (SD); the t‑student test was used for comparing means. Multivariate regression was also used to estimate other sociodemographic and clinical variables associated to HRQOL.

Results: 528 patients were consecutively included, 300 were female (56.8%), 306 with UC (58%) and 222 (42%) with CD. Anaemia was observed in 101 (19.1%) patients. Overall, in most of dimensions of both questionnaires quality of life was better in patients without anaemia, except in three scales of SF-36 where there were not statically significant differences between patients with and without anaemia; these items are Vitality (mean with anaemia 48.95 ± SD 25.88; mean without anaemia 57.95 ± SD 25.41, p = 0.07), Role-Emotional (mean with anaemia 71.00 ± SD 41.21; mean without anaemia 70.53 ± SD 41.85, p = 0.92) and Mental Health (mean with anaemia 64.76 ± SD 21.20; mean without anaemia 65.25 ± SD 21.20, p = 0.85). Nevertheless, after multivariate regression analysis we observed that if we adjusted by other relevant sociodemographic and clinical variables, relapse was the most important risk factor for an HRQOL, and anaemia is only relevant in Role-physical of SF-36 (p = 0.048).

Conclusions: Anaemia does not seem to diminish quality of life in IBD patients, but anaemia associated to a relapse is a risk factor for an impaired quality of life.