Search in the Abstract Database

Search Abstracts 2012

* = Presenting author

P128. Intima–media thickness of the common carotid artery is significantly higher in inflammatory bowel disease patients compared to healthy population

L. Mnif1, A. Grati1, L. Chtourou1, M. Boudabbous1, A. Amouri1, N. Tahri1

1Hedi Chaker University Hospital, Gastroenterology, Sfax, Tunisia

Background: Patients with inflammatory bowel disease (IBD) might have accelerated atherosclerosis due to a chronic systemic inflammation or metabolic changes. Recent studies have discussed whether IBD can predict early atherosclerosis. The aim of our study was to assess the risk of subclinical atherosclerosis in IBD by measuring the intima media thickness of the common carotid artery (IMTc).

Methods: The study consisted of IBD cases (group 1, n = 60) and healthy persons (group 2, n = 60). The IBD group was selected so as not to have vascular disease or the presence of established major cardiovascular risk factors. Carotid ultrasonography was performed in all patients and controls, intima–media thickness was measured proximal to the carotid bifurcation over both right and left common carotid arteries. The clinical characteristics and the laboratory parameters relevant to disease activity were recorded for all IBD patients.

Results: IMTc was significantly higher in IBD patients 0.74±0.23 mm compared with controls 0.49±0.08 mm; p < 0.01. Multiple regression analysis revealed a significant association of IMTc with arterial systolic pressure, HDL‑C and C reactive protein.

Conclusions: IBD patients have an increased risk of early atherosclerosis as shown by greater values of IMTc. Arterial systolic pressure, CRP and HDL‑C were independently associated with the increased arterial wall thickness.