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P140. The relation between resistin and insulin resistance in inflammatory bowel disease patients


E. Ahishali1, S. Ercan2, C. Dolapcioglu1, R. Dabak3, A.O. Kaptanagasi2, O.U. Bayramicli1

1Dr. Lutfi Kirdar Kartal Training and Research Hospital, Department of Gastroenterology, Istanbul, Turkey; 2Dr. Lutfi Kirdar Kartal Training and Research Hospital, Department of Biochemistry, Istanbul, Turkey; 3Dr. Lutfi Kirdar Kartal Training and Research Hospital, Department of Family Medicine, Istanbul, Turkey



Background: Inflammatory bowel disease (IBD) is characterized by anorexia, malnutrition, altered body composition, and development of mesenteric white adipose tissue (WAT) hypertrophy. Preliminary studies have shown overexpression of leptin, adiponectin, and resistin in mesenteric WAT of patients with Crohn's disease (CD) and significant alterations of circulating serum levels of these adipokines in IBD.

In our study we evaluated the relation between resistin and insulin resistance (IR) in IBD patients.

Methods: We compared the inflammatory parameters, clinical activities, serum resistin levels and IR values of 42 IBD patients (31 ulcerative colitis, 11 Crohn's disease) with those of 26 healthy volunteers.

Results: There was no significant difference between the patient and control groups with regard to age, sex, body mass index (BMI), serum resistin levels and IR values. Erythrocyte sedimentation rate and C‑reactive protein levels were significantly higher in IBD patients (p < 0.0001). No statistically significant difference was noted between ulcerative colitis patients, Crohn's disease patients and healthy subjects with respect to age, sex, BMI, serum resistin levels and IR values. Serum resistin levels were significantly higher in IBD patients who had received and/or were receiving steroids (n = 15) when compared to patients who did not receive steroid therapy (n = 27; p < 0.001). There was no difference between these two groups with respect to age, sex, BMI, fasting serum glucose levels and IR values. The disease activity of patients with ulcerative colitis and Crohn's disease was evaluated according to Seo activity index and Crohn's disease activity index, respectively. There was no significant difference between patients with mild disease activity (n = 30) and moderate disease activity (n = 12) with respect to sex, BMI and IR values. Patients with mild disease activity were significantly older (p < 0.05) and had significantly lower serum resistin levels (p < 0.05) compared to those with moderate disease activity.

Conclusions: In our study, serum resistin levels which did not differ between IBD patients and healthy subjects, were elevated parallel to increasing disease activity. Higher serum resistin levels were also found in patients who received steroids owing to disease activation. IBD patients in remission did not display either increase in resistin levels or IR. Neither IBD patients in remission did not display either increase in resistin levels or IR.