P145. Clinical and phenotypic characteristics of Crohn's disease in elderly people: A population-based study
C. Charpentier1, J. Salleron2, G. Savoye3, L. Dauchet2, V. Merle4, J.‑L. Dupas5, A. Cortot6, L. Peyrin-Biroulet7, E. Lerebours8, C. Gower-Rousseau9, J.‑F. Colombel10
1Rouen University and Hospital, Gastroenterology, Rouen, France; 2Lille University Hospital, Epidemiology Unit, Lille, France; 3Hôpital Charles Nicolle, Department of Gastroenterology, Rouen, France; 4Hospital and University, Rouen, France; 5Amiens University Hospital North Hospital, Dept. of Hepagastroenterology, Amiens, France; 6Lille University Hospital, Lille, France; 7University Hospital of Nancy, Hepato-Gastroenterology, Vandoeuvre-Lès-Nancy, France; 8Hôpital Charles Nicolle, Rouen, France; 9Lille University Hospital, Epidemiology Unit, EPIMAD Registry, Lille, France; 10Centre Hospitalier Universitaire de Lille, Hôpital Claude Huriez, Lille, France
Background: The clinical characteristics of Crohn's disease (CD) in elderly people remain poorly documented. The aim of this study was to compare, in a population-based level, the clinical and phenotypic characteristics of CD at diagnosis in two cohorts of patients: patients between 2040 years and patients older than 60 years.
Methods: Two cohorts of patients with definite or probable CD  were identified from the EPIMAD Registry, a population database that prospectively recruited patients diagnosed with IBD between 1988 and 2010.
|At CD diagnosis||2040 y (N = 4626)||>60 y (N = 513)||p|
|% patients with CD vs UC||63||44||<10−5|
|% patients with CCD incidence (/105) [95% CI] D vs UC||12.3 [12.012.7]||2.4 [2.12.7]||<10−6|
|Family history of IBD (%)||14||7||<10−4|
|Extra intestinal manif (%)||8||12||<10−2|
|L2/L3 disease (%/%)||13/46||31/23||<10−4|
|B2/B3 disease (%/%)||30/4||19/13||<10−2|
Results: 5139 patients were included for analysis, of whom 513 were older than 60 y at CD diagnosis. Gender distribution was similar between groups. Time from symptoms-to-diagnosis (mos) was significantly lower in older group than in 2040 yrs group (2 vs 3; p < 104). The clinical and phenotypic characteristics of the study groups at CD diagnosis are presented in the table.
Conclusions: CD is infrequent in patients >60 years. In this age range, it is characterized by a higher frequency of colonic location, extra-intestinal manifestations, penetrating behavior and perianal disease at diagnosis, as compared to a younger population.
1. Gower-Rousseau C (1994), Incidence of inflammatory bowel disease in northern France (19881990). Gut.