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P147. Risks factors concerning bone loss in Moroccan patients with inflammatory bowel diseases

F. Rouibaa1

1Military Hospital mohammed V, Gastroenterology, Rabat, Morocco

Background: Osteoporosis and osteopenia have been reported frequently in patients with inflammatory bowel disease (IBD).

The aim of the study: To determine the prevalence and risk factors of osteoporosis in patients with IBD.

Methods: Prospective study was performed from January 2010 to October 2011 in our center, 96 patients with IBD (55 Crohn's Disease, 41 Ulcerative Colitis) were included, 54 men and 42 women with a mean age of 36±10.4 years (18–68 years) and no history of disorders known to influence bone metabolism. Dual-energy X‑ray absorptiometry measurements of bone mineral density (BMD) were obtained at the femoral neck and lumbar spine. A multivariate model including those factors significantly associated with low BMD in the univariate analysis was used to identify independent risk factors.

Results: Osteopenia was found in 37.7% and osteoporosis in 22.5% of patients. Low BMD was significantly associated with low body mass index (BMI), colonic involvement, and glucocorticoid therapy. Low BMI was an independent risk factor for low BMD. Malnutrition with BMI <18 kg/m2 was noted in 41 patients, of whom 76% had low BMD values, as compared to 49% of the patients whose BMI was >18 kg/m2 (P = 0.02, odds ratio = 3.5).

Conclusions: Among risk factors for bone loss in patients with IBD, malnutrition plays a prominent role that deserves attention when planning treatment programs.