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P221. Lacrimal function in patients with irritable bowel syndrome and inflammatory bowel disease


K. Katsanos1, D.E. Sigounas1, A. Tatsioni2, S. Michalopoulou1, Z.E. Tsianou1, I. Vagias1, V.E. Tsianos1, D.K. Christodoulou1, I. Asproudis3, E.V. Tsianos1

1Medical School of Ioannina, University of Ioannina, 1st Division of Internal Medicine and Hepato-Gastroenterology Unit, Ioannina, Greece; 2Tufts University School of Medicine and Institute for Clinical Research and Health Policy Studies, Department of Medicine, Boston, United States; 3Medical School of Ioannina, University of Ioannina, Division of Opthalmology, Ioannina, Greece



Background: Data concerning lacrimal function in patients with irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) are limited. This study aimed at the detailed documentation and comparison of the findings of lacrimal apparatus tests in patients with irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD).

Methods: A prospective ophthalmological examination of patients with IBS and IBD with emphasis in the function of lacrimal apparatus was conducted using the following methods: (1) Tear-film break up time (BUT), (2) Schirmer‑I test, (3) Rose Bengal dye application. Results were analyzed using Pearson Chi-Square test and a p value <0.05 was considered statistically significant.

Results: A total of 130 patients were studied (89 with IBS, 41 with IBD). There were 63 female IBS and 16 IBD patients. Sixty-one IBS patients (15 male/48 female) and 20 IBD patients (12 male/8 female) had a positive BUT test. Forty-eight IBS patients (17 male/31 female) and 19 IBD patients (11 male/8 female) had a positive Schirmer‑I test. Twenty-two IBS patients (6 male/16 female) and 9 IBD patients (4 male/5 female) had a positive Rose Bengal dye test. Comparisons between patients with IBS and IBD concerning the lacrimal apparatus tests' results were non-significant (Schirmer test: p = 0.51, BUT p = 0.08, Rose Bengal p = 0.76).

Conclusions: This study showed that there are not any significant differences in the function of lacrimal apparatus in patients with IBS and IBD, suggesting that IBS, through a yet undefined inflammatory process, could influence the lacrimal function, as already shown in IBD.