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Search Abstracts 2013

* = Presenting author

Poster presentations: Basic Science (2013)

P001. Interleukin-21 exerts pathogenic and host-protective effects in experimental models of colitis

P002. Intestinal homeostasis is critically regulated by the transcription factor T-bet

P003. Selective inhibition of eIF2alpha dephosphorylation prevents colitis and shows therapeutic potential in a new model of ulcerative colitis

P004. Smooth muscle cells participate in Crohn's disease intestinal fibrosis

P005. T cell KV1.3 channel expression level in biopsies from patients with active ulcerative colitis is higher in patients treated with immunosuppressants and 5-ASA versus 5-ASA alone

P006. Tauro-ursodeoxycholic acid ameliorates experimental colitis in mice

P007. The aetiology, immune activation and homing profile of dendritic cells in fistulating perianal Crohn's disease

P008. The amount of keratins in colonic epithelial cells matter for stress protection

P009. The changes of the NO-ergic system, arginase and oxidative processes in the muscular layer of the colon under the conditions of stress and experimental colitis

P010. The effect of interleukin-1 receptor antagonism in the management of intestinal inflammation; an in vitro and in vivo study

P011. The effect of melatonin treatment on DSS induced colitis and probable mechanism by microarray

P012. The effects of faecal microbiota transplantation on the innate immune system and epithelial tight junction expression in chronic refractory pouchitis

P013. The fall of estrogen receptors expression in long-lasting ulcerative-associated carcinoma

P014. The inflammasome induces macrophage-mediated disruption of the epithelial barrier

P015. The influence of COX-1/COX-2 inhibitors on the Na/Li-countertransport and Na,K,2Cl-cotransport in erythrocytes of rats with experimental colitis

P016. The lack of tumour necrosis factor alpha downregulation on basic fibroblast growth factor/syndecan 1 link may be a relevant molecular pathway in Crohn's disease fibrotic stenosis

P017. The miRNA-29 family regulates NOD2-dependent IL-23 expression in human DCs and limits intestinal pathology in a mouse model of mucosal inflammation

P018. The role of human colonic ion transporters in diarrhea-associated diseases

P019. The role of human neutrophil elastase and its inhibitor elafin in ulcerative colitis

P020. The Th17 cell population in the peripheral blood in patients with Crohn's disease

P021. The urokinase plasminogen activator receptor (uPAR) regulates intestinal macrophage phagocytosis and polarization in experimental colitis

P022. Therapeutic effect of adipose tissue-derived stem cell in Interleukin-10 knockout mice

P023. Therapy with FREMS (Frequency Rhythmic Electrical Modulation System)

P024. Ulcerative colitis versus Crohn's disease: differences observed in the IMPACT survey

P025. Vedolizumab does not affect the suppressive activity of gut-homing T regulatory cells

P026. Vitamin D enhances macrophage function and improves killing of Crohn's associated E. coli

P027. Vitamin D potentiates the immunosuppressive effect of anti-TNF induced regulatory macrophages

P028. Inflammatory cytokines specifically regulate endoplasmic reticulum stress in colitis

P029. Inflammasome activation P2X7-dependent in Crohn's disease

P030. High fat diet aggravates Crohn's disease-like ileitis independently of obesity via alterations of epithelial barrier homeostasis

P031. Simultaneously restoration of Foxp3 (+) regulatory T cells subsets, type 1-like regulatory T cells and B cells correlates with clinical response to infliximab therapy for IBD

P032. Serum hepcidin in inflammatory bowel diseases

P033. Serum hepcidin expression varies with disease activity in Crohn's disease

P034. Serum concentration of estrogen is associated with inflammatory bowel disease activity

P035. Salicin ameliorates the inflammation and prevents the loss of gut flora in DSS induced mice model of colitis

P036. SPARC affects colorectal tumourigenesis

P037. Role of ghrelin and melatonin in pathogenesis of clinical and experimental inflammatory bowel disease

P038. Role of 5-HT3 receptors in the anti-inflammatory effects of alosetron in a rat model of colitis

P039. Reprogramming of intestinal epithelial cells by interleukin-22

P040. Protein tyrosine phosphate non receptor type 22 regulates muramyl-dipeptide induced effects in human monocytes

P041. Piroxicam-accelerated colitis in interleukin-10 knock out mice – a “new” model of human inflammatory bowel disease

P042. Patients' preferences when selecting biologics for inflammatory bowel disease

P043. PRKCDBP, a new transcriptional target of TNF-alpha signaling pathway in ulcerative colitis

P044. Novel image using hydrogen sulfide multiphoton probe in the mucosal tissue of ulcerative colitis patients

P045. Mycobacterium avium subsp. paratuberculosis survival in macrophages from inflammatory bowel disease patients

P046. Mucosal immune activation in diarrhea-predominant irritable bowel syndrome: comparison with health controls and ulcerative colitis

P047. Metformin inhibits NF-κB signaling in intestinal epithelial cells, and ameliorates experimental colitis and colitis-associated colon cancer in mice

P048. Metallothionein, an emerging danger signal during experimental colitis

P049. Longitudinal assessment of epithelial and immune cell changes following ileostomy closure in patients with ulcerative colitis

P051. Inhibition of lymphangiogenesis via VEGFR-3 as a novel therapy for IBD-related colorectal cancer

P052. Inhibition of Th17 cells but not of Tregs affects extracellular matrix protein deposition in chronic DSS colitis

P053. Influence of NADPH oxidase on inflammatory response in the primary intestinal epithelial cells from patients with ulcerative colitis

P054. In experimental model of colitis the therapeutic efficacy of mesenchymal stem cells is not gut-homing dependent but is mediated at distance by secretion of TNF-alfa stimulated gene/protein 6

P055. HDAC dependent regulation of the IL-6/STAT3 pathway during T helper cell activation

P056. GED-0507–34 Levo, a novel modulator of PPARgamma as new therapeutic strategy in the treatment of intestinal fibrosis

P057. Micro-RNA expression profiling identifies miR-29b as a relevant pro-fibrogenic factor in Crohn's disease intestinal strictures

P058. In vivo formation of 8-iso-prostaglandin F2 α and platelet activation in inflammatory bowel disease

P059. Immunohistochemical expression of angiopoietin 1 (Ang1), CD34 and D2.40 in colon of patients with inflammatory bowel disease (IBD) and its association with endoscopic activity

P060. Immune unresponsiveness of human intestinal dendritic cells in ulcerative colitis is reversed by a novel bacterial peptide STp

P061. Ileum versus colon: separate roles for gut dendritic cells in mucosal immune homeostasis and implications for ulcerative colitis

P062. Ileal gene expression profiling of Crohn's disease underlines the importance of the inflammatory load during the disease course

P063. IL-21 and IL-21 receptor expression in the intestine from patients with Crohn's disease

P064. IL-21 neutralization in experimental colitis: regulation of cytokines, chemokines and colonic transcripts

P065. Humoral immune response to intestinal microbiota in inflammatory bowel diseases

P066. Human intestinal Vδ2+ T-cells promote mucosal inflammation in Crohn's disease and are selectively ablated by azathioprine therapy

P067. Human and rodent ex vivo model for intestinal fibrosis in inflammatory bowel disease (IBD)

P068. High expression level of the T cell potassium channel, KV1.3, is a novel diagnostic marker of inflammatory activity in patients with ulcerative colitis

P069. Glycine and glutamine down-regulate IL-6-induced claudin-2 expression in human colonic epithelial cell monolayer

P070. Genetic polymorphisms of interleukin 15 (IL-15) in patients with ulcerative colitis

P071. Gelenterum ameliorates murine colitis while modulating gut microbiota and intestinal mucus layer

P072. Ezrin, LAMC2 and ITG α 6 as possible biomarkers of ulcerative colitis-associated colonic dysplasia

P073. Ex vivo activation of triggering receptor expressed on myeloid cells 1 enhances the production of pro-inflammatory cytokines by inflammatory bowel disease mucosa

P074. Extracellular matrix protein expression in chronic repeated DSS colitis reflects transmural remodeling in human Crohn's disease

P075. Evolutive profile of biomarkers in postoperative Crohn's disease patients: identification of recurrence risk predictors

P076. Epithelial apoptotic loss is enhanced even in tissue from uninflamed mucosa in patients with Crohn's disease

P077. Emerging role of the interleukin (IL)-33/ST2 axis in gut mucosal wound healing and epithelial repair

P078. Efficacy of human anti-macrophage migration inhibitory factor antibodies in mouse models of inflammatory bowel disease

P079. Effects of a mixture of amino acids on colonic mucosa healing after experimental colitis

P080. Effect of insulin like growth factor-1 on experimental colitis

P081. Effect of condroitin sulphate on pro-inflammatory mediators and disease activity in patients with inflammatory bowel disease (IBD)

P082. Altered oligosaccharide structures reduce colitis induction in mice defective in glycosyltransferases

P083. ADAMDEC1: a novel molecule linked to Crohn's disease, is associated with an increased susceptibility to Citrobacter rodentium colitis in the knock out mouse

P084. Effect of infliximab on monocyte subtypes in blood of patients with chronic inflammatory bowel disease

P085. Effect of phytoestrogenic dietary supplementation on the progression of chronic intestinal inflammation to cancer in an animal model

P086. Donor dependent efficacy of human mesenchymal stromal cell treatment in experimental colitis

P087. Differentially expressed microRNAs regulate expression of genes with clinical interest in inflamed colon of patients with ulcerative colitis

P088. Differential expression of prolyl hydroxylases 1 and 3 between IBD and non-IBD patients

P089. Differential effects of sulphasalazine, azathioprine and prednisolone on the NF-kB, heparanase, HSP70 and HPRT gene expression in the TNBS-induced intestinal inflammation

P090. Differential effects of sulphasalazine, azathioprine and prednisolone on the MAP-kinases gene expression in the TNBS-induced intestinal inflammation

P091. Development of a patient-reported outcome measure for Crohn's disease

P092. Detection of apoptosis in intestinal mucosa and mesenteric fat tissue of Crohn's disease

P093. Dendritic cell characteristics in pouchitis

P094. Defective CSF2RB signaling in Crohn's disease patients bearing the NCF4 risk allele

P095. Dipotassium glycyrrhizate ameliorates DSS-induced colitis in mice by HMGB1 inhibition

P096. Circulating components of the alternative renin–angiotensin system are upregulated in patients with inflammatory bowel disease

P097. The efficacy of benzoxazole derivatives (B-98) as 5-lipooxygenase inhibitor and the change of T cell profiles in acute murine colitis model

P098. Association study of genetic variants in miRNAs in patients with inflammatory bowel disease

P099. Anti-TNF-alpha treatment improves carbohydrate metabolism in patients with inflammatory bowel disease

P100. A novel therapeutic target linking diet to disease pathogenesis in ulcerative colitis: the aryl hydrocarbon receptor

P101. Analysis of the protease MT1-MMP and its substrates as biomarkers in IBD

P102. Altered epithelial tight junction expression and elevated IL 6 levels in pouchitis

P103. Adding fuel to the fire – neutrophils as antigen presenting cells in Crohn's disease

P104. Adalimumab for induction of clinical remission in moderately to severely active ulcerative colitis in Mexican population

P105. Active inflammation of the appendix in ulcerative colitis

P106. Active macrophage migration inhibitory factor (MIF) is a previously unrecognized isoform of MIF and a potential new biomarker for inflammatory bowel diseases

P107. Action of leukocytapheresis is associated with calcitonin gene-related peptide induction in colitis models

P108. FAM5C, a possible causal molecule in ulcerative colitis revealed through a transcriptomic analysis of the bowel mucosa