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20. Mortality and causes of death in ulcerative colitis: results from a Norwegian population based study during a twenty years period of follow-up (the IBSEN study)

I.L.K. Monstad1, O. Hovde2, M. Cvancarova3, I.C. Solberg1, B. Moum1, 1Oslo University Hospital, Ullevaal, Department of Gastroenterology, Oslo, 2Innlandet hospital Trust, Gastroenterology, Gjovik, 3University of Oslo, Section for Biostatistics, Oslo, Norway

Background

There is a lack of studies addressing mortality and causes of death in unselected cohorts of patients with ulcerative colitis (UC). This study aimed to evaluate mortality and causes of death during the first 20 years after diagnosis in a well-characterised population based UC cohort.

Methods

The study group on Inflammatory Bowel disease in South East Norway (IBSEN) has prospectively followed all patients diagnosed with inflammatory bowel disease from four geographically well defined areas in the period from January 1990 to December 1993. In total 519 UC patients were enrolled in the inception cohort. Each patient was sex and age matched with 25 controls selected at random from the background population within the same county. Data on death and causes of death were collected from the Norwegian Cause of Death Registry. All causes and cause specific mortality (cancer, GI cancer specifically, and heart disease) were modelled with Cox regression stratified by matched sets. Results are expressed as overall mortality with 95% Confidence Interval (CI).

Results

A total of 509 UC patients were included in the present analysis. The patients were age and sex matched with 12581 controls. The overall mortality for males after 10 years was 12.7% (95% CI 9.2–17.4) and 23.7% (95% CI 18.7–29.8) after 20 years. For females, the overall mortality after 10 and 20 years was 10.8% (95% CI 7.5–15.5) and 17.5% (95% CI 13.1–23.1) respectively. Overall, UC patients exhibited a slightly higher mortality than their matched controls, allthough this was not statistically significant (hazard ratio = 1.14, 95% CI 0.93–1.40).

Conclusion

Neither the overall mortality, nor the cause specific mortality were significantly increased in this population based cohort of UC patients followed up for 20 years after initial diagnosis.