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P042. Patients' preferences when selecting biologics for inflammatory bowel disease

E. Tsiaousi1, C. Tzathas2, C. Zeglinas2, G. Michalopoulos2, G. Kouklakis3, A. Babali3, S. Polyzos1, G. Tsarouchas1, C. Stergiopoulos1, S. Michael1, K. Anastasiadou1, J. Kountouras1, 1Aristotle University of Thessaloniki, 2nd Medical Clinic, Thessaloniki, Greece, 2Tzanio General Hospital, Piraeus, Gatsroenterological Clinic, Athens, Greece, 3Dimokrition University of Thrace, Gatsroenterological Clinic, Alexandroupolis, Greece

Background

Selectic biologics (infliximab and adalimumab) appear to be equally efficacious in the treatment of inflammatory bowel disease (IBD) and therefore the decision regarding which drug to choose will depend to some extent on patient choice. The aim of the study was to identify the IBD patients' preferences when selecting biologics (anti-TNF) concerning the setting (hospital or home) and route of administration.

Methods

A prospective survey was performed among anti-TNF-naïve or not Crohn's disease (CD) and ulcerative colitis (UC) patients in three Greek Gastroenterology Centers. All patients completed a questionnaire addressing their perceptions of current biologic treatment and mainly the preferences for the setting and the route of administration (iv or sc).

Results

159 patients completed the questionnaire (95 CD and 64 UC). Based on the information provided, 59.75% of patients preferred hospital administration of anti-TNF agents and 40.25% self-administration at home. There was a variability among the three participating centers concerning hospital iv administration of biologics (78%, 53.33% and 50.63% in Thessa­loniki, Alexandroupoli and Athens, respectively). Reasons for the choice of i.v. administration were the safety of treatment at the hospital and the supportive effect of physician's presence. The s.c. administration was chosen for the convenience of treatment and in particular for home treatment. Patients' preferences parameters were: age, sex and education-socioeconomic status. Patients >35 years preferred hospital iv administration by 62% whereas younger patients by 55.22%. Female patients were in favor of hospital iv administration by 63.51% while male patients by 56.47%. Patients with higher education and socioeconomic status showed a greater preference towards sc self-administration 55.6% vs 68.0%.

Conclusion

IBD patients seem to prefer hospital iv administration of anti-TNF agents with women, adult aged and patients with lower socioeconomic and educational status showing a greater tendency towards this preference. Patients' individual preferences should be perhaps taken into account when prescribing anti-TNF drugs. Further studies are needed in IBD Greek patients to investigate whether patient choice will affect adherence, satisfaction and efficacy of treatment with anti-TNF agents.