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P118. Vitamin D status and bone mineral density in patients recently diagnosed with ulcerative colitis

G. Dumitrescu1, I.A. Pintilie1, M. Dranga1, E. Toader1, C. Mihai1, C. Cijevschi Prelipcean1, 1University of Medicine and Pharmacy Gr. T. Popa, Center of Gastroenterology and Hepatology “St. Spiridon” Hospital, Iasi, Romania

Background

Introduction: Inflammatory bowel diseases (IBD) are associated with an increased prevalence of decreased bone mineral density. One of the risk factors for the low bone mineral density is the inadequate level of 25 OH vitamin D.

The aim of this study was to evaluate bone mineral density and level 25 OH vitamin D in patients recently diagnosed with UC.

 

Methods

A prospective study was performed in The Center of Gastroenterology and Hepatology and included patients recently diagnosed with UC. We noted demographic and clinical data (age, sex, extent of lesions, the degree of disease activity and treatment). 25 OH vitamin D level was measured in all patients and dual-energy X-ray absorptiometry (DEXA) was performed at lumbar level and femoral neck.

Results

134 patients with UC were included; they had an average age of 46.21 years and were mostly men (59.7%) with an average evolution of the disease about 4 years (65% with an evolution <1.5 years or recently diagnosed). Most patients had extensive forms of the disease (56% left colitis, pancolitis 25.4%). In terms of disease activity: 29.9% had severe activity, 32.8% moderate, 23.9% mild and 13.4% were in clinical and biological remission. 29.1% of patients required treatment with oral or intravenous corticosteroids for about 4 months. Based on the lumbar and femoral neck osteodensitometry: 33.58% had normal BMD, 48.5% osteopenia and 17.91% osteoporosis. 25 OH vitamin D level was insufficient (<30 ng/ml) in 47% patients, normal in 31.34% patients, and 29 patients (21.64%) presented sever 25 OH vitamin D deficiency (<20 ng/ml).

Conclusion

Decreased bone mineral density occurs early after the diagnosis of UC. Vitamin D deficiency is induced by extensive lesions and also by the inflammatory process. Vitamin D deficiency and the use of corticosteroids represent important risk factors in the development of bone demineralization in patients newly diagnosed with UC.