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P155. Relationship between weight, body mass index and bone mineral density in inactive inflammatory bowel disease patients under 50 years old

W. Moon1, T.O. Kim2, S.J. Park1, M.I. Park1, H.H. Kim1, 1Kosin University, Department of Internal Medicine, Busan, South Korea, 2Inje University, Department of Internal Medicine, Busan, South Korea

Background

This study aims to identify a relationship between weight, body mass index (BMI) and bone mineral density (BMD) of lumbar spine and femur neck in patients under 50 years old with inactive Crohn's disease (CD) and ulcerative colitis (UC).

Methods

The subjects were CD and UC patients under 50 years old who were regularly followed up in an inflammatory bowel disease center in Korea. The associations between BMD and clinical parameters including weight, height, BMI, disease-onset age, disease-duration, time of disease onset to diagnosis, and biochemical parameters including hemoglobin, c-reactive protein, serum albumin, calcium and phosphorus were evaluated. BMD was measured as Z-score and low BMD was defined less than −1.

Results

In enrolled 73 CD (male, 51; 69.9%) and 114 UC (male 72; 63.2%), 34 (46.6%) and 49 (43.0%) were low BMD, respectively without difference between two diseases and sex. In CD, mean weight and BMI in low BMD group were lower than those in normal BMD group (59.1 vs. 65.1, p = 0.23 and 20.4 vs. 22.8, p = 0.001). BMI was correlated with BMDs of lumbar spine and of femur neck (0.320, p = 0.006; 0.390, p = 0.001) but weight was correlated only with BMD of femur neck (0.376, p = 0.001). In UC, mean weight and BMI in low BMD group were lower than those in normal BMD group (58.2 vs. 63.9, p = 0.009 and 20.5 vs. 22.5, p < 0.001). BMI was correlated with BMDs of lumbar spine and of femur neck (0.249, p = 0.007; 0.433, p < 0.001) but weight was correlated only with BMD of femur neck (0.406, p < 0.001). Other clinical and biochemical parameters were irrelevant to BMD in CD and UC.

Conclusion

Low weight and BMI could reflect the possibility of low BMD in patients under 50 years old with inactive CD and UC.