Search in the Abstract Database

Search Abstracts 2013

* = Presenting author

P161. Quality of life in remission of inflammatory bowel disease: overlap with irritable bowel syndrome

E. Bodryagina1, D. Abdulganieva1, A. Odintsova2, 1Kazan State Medical University, Department of Internal Medicine, Kazan, Russian Federation, 2Republican Clinical Hospital, Kazan, Russian Federation

Background

The aim of our study to evaluate quality of life (QoL) in patients with inflammatory bowel disease (IBD) remission.

Methods

QoL was evaluated in 36 patients with remission of IBD, 38 patients with irritable bowel syndrome (IBS) and 59 healthy controls. We used IBDQ and SF-36 questionnaires. Remission of IBD was defined in ulcerative colitis (UC) as Mayo ≤2; in Crohn's disease (CD) as CDAI ≤150. Among IBD patients male was 16 (44.4%), female – 20 (55.6%). Diagnosis of UC was in 15 (41.7%) patients, CD – in 21 (58.3%) patients. The mean age of patients was 34.6±3.2 years. The mean disease duration – 4.8±1.6 years. 38 patients with IBS according to the Rome Criteria III were also included. The mean age was 33.4±2.3 years, female – 26 (68.4%), male – 12 (31.6%). IBS symptoms were present about 9.7±3.0 years. The control group was matched by sex, age and other socio-demographic characteristics.

Results

QoL was markedly decreased in different patient groups. Physical health decrease was more prominent in patients with IBD compared with IBS (42.9 points vs 49.3 points; p < 0.05); mental health changes were opposite – significant reduction in mental pattern in patients with IBS compared with IBD patients (32.3 vs 48.6; p < 0.001). In the control group the mean value of physical constants was 55.2 points, which is significantly higher comparing with patients with IBD (p < 0.001) and patients with IBS (p < 0.05), mental health score was 56.4, which also higher compared with those of IBD (p < 0.001) and IBS (p < 0.0001).

Clinical evaluation of IBD patients showed that some of them had clinical symptoms of IBS: in 5 (33.3%) UC patients, 6 (28.6%) CD – a group with IBS-like syndrome. It was found a more significant reduction of QoL in patients with concomitant IBS-like syndrome compared with IBD patients without it (119.2 vs 168.3; p < 0.01). Also, patients with the presence of IBS-like syndrome had a marked reduction of both physical (38.1 vs 53.8; p < 0.0001) and mental health (35.3 vs 53.6; p < 0.0001) (by SF-36), whereas in the subgroup of patients without concomitant IBS, these figures (53.8 vs 55.2; p > 0.05; 53.6 vs 56.4; p > 0.05) respectively were close to the controls.

Conclusion

QoL is reduced in patients with IBD in remission. The more prominent decrease of QoL was observed in in subgroup of IBD patients with presence of IBS-like syndrome.