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P182. Prevalence of colonic diverticulosis in patients affected by ulcerative colitis versus adult patients in a single centre

E.V. Avallone1, C. Cassieri1, R. Pica1, M. Zippi1, P. Paoluzi1, 1Sapienza University, Internal Medicine and Medical Specialties, “Gastroenterology Unit”, Rome, Italy

Background

Diverticulosis of the colon is an acquired condition that results from herniation of the mucosa through defects in the muscular layer. Several studies have revealed that diverticular formation of the colon occurs primarily in industrialized and Westernized countries. The true prevalence of colonic diverticulosis is difficult to measure because most individuals are asymptomatic. In particularly, in literature, there are few studies about the prevalence of colonic diverticulosis in patients affected by ulcerative colitis (UC). Aim of this study has been to investigate the prevalence of colonic diverticulosis in UC and in adult patients referred in a single centre.

Methods

Computerized data of consecutive patients, referred to our Institution to undergo a colonoscopy for colorectal cancer screening and/or for UC control, between January 1, 2009 and December 31, 2009, were retrospectively studied.

Results

Six hundred and five consecutive patients, referred to our Institution to undergo a colonoscopy between January 1, 2009 and December 31, 2009, were retrospectively studied. Of these patients, 438 (72.4%) underwent colonoscopy for colorectal cancer screening (Group A) and 167 (27.6%) for UC control (Group B). In group A 224 patients (51.1%) were male (average age of 62.7±14.2 SD years, range 35–86 years), in group B 102 (61.1%) were male (average age of 57.6±12.1 SD years, range 25–84 years). Prevalence of colonic diverticulosis was higher in group A (122 patients, 27.8%) than group B (18 patients, 10.8%) a difference statistically significant (p < 0.0001, Fisher's exact test). In particularly female gender in patients with colonic diverticulosis was higher in group A than group B (68 patients and 4 patients, respectively) with a difference statistically significant (p < 0.0001, Fisher's exact test). No differences were found between the two groups in terms of extension of colonic diverticulosis.

Conclusion

Results of our study demonstrated that prevalence of colonic diverticulosis was significantly lower in patients with UC than in adult population, emphasizing the relevance of the coexistence of UC and colonic diverticulosis because could make very difficult the clinical management of these patients.