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P229. Is quality-of-life worse in perianal Crohn's disease patients?

M. Barreiro-de Acosta1, M. Iglesias-Rey1, A. Lorenzo1, J.E. Dominguez-Munoz1, 1University Hospital, Gastroenterology, Santiago, Spain

Background

A high proportion of Crohn's disease (CD) patients develop perianal behavior during the evolution of the disease, these kinds of patients being those who need more aggressive therapies. The aim of this study was to assess if perianal disease was associated with a worse health-related quality of life (HRQOL) in CD patients regardless of the activity of the disease.

Methods

A cross-sectional, prospective study with consecutive patient recruitment was designed. All adult patients with CD who attended our IBD Unit were included. Perianal disease was defined as presence of fistulas, abscesses and stenosis, alone or in combination in accordance with the p subgroup the in Montreal Classification. To assess quality of life we used the IBDQ, which included five dimensions (Table 1). Total scores range from 36 to 252. We also used the SF-36 questionnaire, which included 8 scales (Table 2). Total scores range from 0 to 100. In both cases, higher scores indicate better HRQOL. Results are shown as mean and standard deviation; the t-student test was used for comparing means.

Results

323 patients were consecutively included (mean age of 39 years, age range 18–81 and a mean of 10.5 years since diagnosis); 186 (57.6%) were female and 206 patients (63.8%) were in remission. 44 patients (14%) presented perianal behaviour. In all the dimensions from both questionnaires there were no significant differences in quality of life among CD patients with or without perianal disease. In Tables 1 and 2 the means and p values of IBDQ and SF-36 dimensions are shown respectively.

Table 1. IBDQ Questionnaire in patients with and without perianal disease
PerianalBowel SymptomsSystemic SymptomsFunctional ImpairmentSocial ImpairmentEmotional Function
Yes5.605.225.435.725.42
No5.314.995.205.765.22
p0.190.370.440.850.59
Table 2. SF-36 Questionnaire in patients with and without perianal disease
PerianalGeneral HealthPhysical FunctioningRole-PhysicalVitalityRole-EmotionalSocial FunctioningBodily PainMental Health
Yes83.2369.549.4554.0375.068.1466.0666.83
No81.3661.2347.6052.9474.2972.0465.1161.58
p0.670.350.660.840.900.640.830.35

Conclusion

Patients with perianal CD, irrespective of the activity of the disease, do not have worse quality of life than those without perianal disease.