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P269. Correlation between soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) expression and endoscopic activity in intestinal Behcet's disease

H.S. Shin1, H.J. Lee1, S.J. Park1, S.P. Hong1, T.I. Kim1, W.H. Kim1, J.H. Cheon1, 1Yonsei University College of Medicine, Department of Internal Medicine and Gastroenterology, Seoul, South Korea

Background

The serum level of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) has recently been shown to be highly correlated with disease activity in patients with intestinal Behcet's disease (BD). However, it remains unclear whether sTREM-1 level reflects endoscopic activity in intestinal BD. This study aimed to evaluate the correlation of sTREM-1 level with endoscopic activity in intestinal BD.

Methods

A total of 84 patients with intestinal BD were enrolled. Endoscopic activity was determined using a novel endoscopic severity model composed of variables including location, number, depth, shape, and size of ulcer in patients with intestinal BD. At the time of colonoscopy, sTREM-1 level as well as other laboratory findings including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were measured and compared with endoscopic activity.

Results

The number of patients with active ulcer was 61 (72.6%) and that with healed ulcer was 23 (27.4%). The mean ESR and CRP levels in patients with active ulcer were significantly higher than those in patients with healed ulcer (36.2 mm/h vs. 20.7 mm/h, p = 0.001 and 1.6 mg/dL vs. 0.3 mg/dL, p = 0.001, respectively), whereas the mean sTREM-1 level in patients with active ulcer was not different from that in patients with healed ulcer (43.5 pg/ml vs. 42.2 pg/ml, p = 0.819). Moreover, an endoscopic activity score for intestinal BD was significantly correlated with both the CRP level (r = 0.329, p = 0.002) and ESR (r = 0.298, p = 0.006), but not with sTREM-1 level (r = 0.166, p = 0.132).

Conclusion

Serum sTREM-1 level was not correlated with endoscopic activity than was CRP level or ESR in patients with intestinal BD, suggesting that serum sTREM-1 level may not be a useful marker for the assessment of endoscopic activity in intestinal BD.