P321. Vitamin D level doesn't correlate with disease extent and severity in Hungarian patients with inflammatory bowel disease
K. Lorinczy1, P.L. Lakatos2, Á. Salamon3, A. Nemes3, B. Fekete1, O. Terjék1, Á. Csontos1, T. Pere3, L. Herszényi1, Z. Tulassay1, P. Miheller1, 1Semmelweis University, 2nd Department of Internal Medicine, Budapest, Hungary, 2Semmelweis University, 1nd Department of Internal Medicine, Budapest, Hungary, 3János Balassa Tolna County Hospital, Department of Gastroenterology, Szekszárd, Hungary
Recent studies have shown that vitamin D has an important role in the immune regulation. Vitamin D is essential for innate and adaptive immune system, it plays an important role in the formation of immune tolerance, as well. Vitamin D deficiency has been observed in several western IBD (inflammatory bowel diseases) populations, but there is no data available about IBD patients from Eastern Europe.
We included 161 IBD patients (46 with UC (Ulcerative Colitis), 115 with CD (Crohn's disease); female/male: 82/79) into the study. Mean age of the patients 35.9±11.7 years. Disease extent of UC and CD was defined based on the Montreal Classification (E1–3 and L1–3, respectively). Vitamin D insufficiency was defined as a level below 15 and 30 ng/ml, deficiency was defined as a level under 15 ng/ml. Calculations were performed using SPSS statistics 15.0 software. Paired and independent sample Student's t-tests, Pearson correlations were applied.
Fifty-two percent of IBD patients had vitamin D insufficiency (CD: 53%, UC: 48%), 28% of them (CD: 25%, UC: 33%) had severe vitamin D deficiency. Only 20% of the IBD patients (CD: 22%, UC: 19%) had adequate vitamin D level (>30 ng/ml). The median vitamin D level was 22.74±10.61 ng/ml. Vitamin D levels did not differ regarding the type of the IBD (23.65±11.19 ng/ml vs. 19.89±7.66 in CD vs. UC; NS). There were no significant difference in vitamin D levels considering disease extent (CD-L1: 23.94±7.99 ng/ml, CD-L2: 23.79±8.62 ng/ml, CD-L3: 22.23±12.67 ng/ml; NS and UC-E1: 19.27±6.68 ng/ml, UC-E2: 19.60±6.54 ng/ml, UC-E3: 18.93±8.49 ng/ml; NS). Vitamin D concentration did not correlated neither to clinical activity indexes (partial Mayo score: r = −0.143; Crohn's disease activity index: r = −0.253) nor inflammatory parameters (C-reactive protein: r = 0.008; erythrocyte sedimentation rate: r = 0.012).
Vitamin D deficiency is common in Hungarian patients with IBD. In contrast with results of previously performed studies, our results show that Vitamin D concentration is independent from disease extent or severity in IBD patients. However, methodological differences of Vitamin D determination, seasonal variation of blood sample taking and other important factors need to be considered while evaluating the different results.