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P332. To identify various profiles of IBD patients and differences in HRQOL

S. Jäghult1, D. Andersson1, F. Saboonchi1, 1Karolinska Institutet Danderyds sjukhus, Department of Clinical Sciences, Stockholm, Sweden

Background

Studies have shown that patients with IBD rate their health-related quality of life (HRQOL) lower compared to the general population. Many studies have been made on patients' HRQOL related to IBD, and diagnosis, gender and age are considered to be important contributing factors.

Aim: The aim of this study was to identify various profiles of IBD patients based on gender, age and diagnosis, and to examine differences on HRQOL across these profiles.

Methods

The Short Health Scale (SHS) measures HRQOL in IBD patients and consists of four questions regarding symptoms, function, disease-related anxiety and well-being respectively.

SWIBREG is a Swedish national registry for IBD patients, with the aim to eventually include all Swedish IBD patients. For this study, all patients registered in SWIBREG during 2010–2011 that also had completed the SHS questionnaire were included. The data were collected during annual routine controls by telephone, with patients who during their latest outpatient contact had been in clinical remission.

Two step cluster analysis was utilised to accommodate for categorical variables. The differences in HRQOL were assessed by means of MANOVA.

Results

A total of 203 (94 men, 109 female) patients were included. There were 113 patients with UC, 80 patients had CD, and 10 had indeterminate colitis. The mean age was 55 years (SD 15.501).

Cluster analysis returned 4 different profiles; cluster 1 (females with UC, age below average), cluster 2 (men with UC, age below average), cluster 3 (women with predominantly CD (80%), age above average), and cluster 4 (men with CD, age around average).

MANOVA with ANOVA and post hoc analysis displayed that cluster 3 reported significantly more symptoms (p < 0.05) compared to all three of the other clusters.

Cluster 3 also reported reduced function in their daily life related to their IBD, though this was only significant compared to cluster 2.

Conclusion

Present study shows that in this study population, women with age above average suffering from IBD (predominantly CD) reported more symptoms and had reduced function scores related to their IBD even in routine checkups during periods of supposed remission.

These results suggests that using data from national register databases like SWIBREG might help IBD centres to identify patient groups that might need more support and increased IBD health care availability.