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P450. Long-term impacts of colectomy surgery among ulcerative colitis patients study (LOCUS): the final analysis

C. Brown1, P. Gibson2, A. Hart3, G. Kaplan4, E. Hautamaki5, E. Flood5, T. Fan6, L. Stokes6, K. Beusterien5, 1St. Paul's Hospital, Division of General Surgery, Vancouver, Canada, 2The Alfred Hospital, Department of Gastroenterology, Melbourne, Australia, 3St. Mark's Hospital NWLH NHS Trust, Department of Medicine, London, United Kingdom, 4University of Calgary, Departments of Medicine and Community Health Sciences, Calgary, Canada, 5Oxford Outcomes Inc., Bethesda, United States, 6Merck & Co., Whitehouse Station, United States


A host of potential post-operative complications and lifestyle changes may impact patients' health-related quality of life (HRQL) among ulcerative colitis (UC) patients who received colectomy surgery. Studies assessing the long-term impacts of colectomy on overall quality of life, productivity, body image, sexual functioning, and psychosocial functioning are limited. The objective of LOCUS is to evaluate the long-term consequences of colectomy from the patient's perspective.


A cross-sectional survey was conducted in Canada, Australia, and the UK, on 421 patients from 18 to 65 years of age with UC who underwent colectomy at least one year prior to study enrollment; surgical centers in Canada (n = 3), the UK (n = 3), and Australia (n = 6) recruited eligible patients based on a consecutive sample to ensure generalizability. Participants completed a web or paper survey with measures including the Inflammatory Bowel Disease Questionnaire (IBDQ), Hospital Anxiety and Depression Scale (HADS), EQ-5D, and sexual functioning and fertility, work productivity, dietary restrictions, preferences/satisfaction scales. Dates of colectomy-related surgeries and complications were recorded from medical charts.


A total number of 421 patients were recruited with ongoing assessments of anxiety and depression on daily activity due to bowel condition, and evaluation of cumulative IBDQ and EQ-5D scores, sexual functioning and fertility, dietary restrictions, work productivity, and medication use. Moderate-to-severe UC pre-colectomy versus post-colectomy and pouch versus stoma and UC versus general population quality of life stratifications are considered in measurement parameters, as applicable.


The study will help inform physicians and patients set reasonable expectations regarding quality of life after colectomy.