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P561. Comparison of clinical characteristics of inflammatory bowel disease patients according to the age of diagnosis

E.Y. Kim1, E.S. Kim2, K.B. Cho2, K.S. Park2, B.I. Jang3, K.O. Kim3, C.H. Yang4, 1Catholic University of Daegu School of Medicine, Internal Medicine, Daegu, South Korea, 2Keimyung University School of Medicine, Internal Medicine, Daegu, South Korea, 3Yeungnam University College of Medicine, Internal Medicine, Daegu, South Korea, 4Dongguk University Hospital, Internal Medicine, Kyungju, South Korea

Background

Although inflammatory bowel disease (IBD) has different epidemiologic and clinical characteristics depending on various factors, they have yet to be fully demonstrated according to the patients' age of diagnosis. The aim of this study was to compare clinical characteristics based on the age when patients had been diagnosed.

Methods

We recruited consecutive patients who were diagnosed of IBD at 2 tertiary hospitals and reviewed their medical information retrospectively. Diagnosis was made by clinical, radiological, endoscopic, and pathologic features after at least 1 year follow-up period. Patients were divided into 3 groups by age of diagnosis: young (<17 years), mid (17–40 years), and old (>40 years). The main characteristics of comparison were achievement of remission state at patient's last visit, surgery, and cumulative use of immunosuppressant or anti-TNF blockers during follow-up (mean 66.03±60.28 months).

Results

A total of 346 patients were included in this study (Crohn's disease (CD) 146, ulcerative colitis (UC) 200; young 31, mid 202, old 113). Perianal disease was more common in young group of CD patients (p = 0.006). Disease extent of UC patients was not different between groups. Overall, the achievement of remission at last follow-up visit was less observed in young group than mid or old group (67%, 81.7%, and 91.2%, respectively, p = 0.005). Surgery was more required in young group than mid or old group (36%, 14%, and 3%, respectively, p < 0.001). Cumulative immunosuppressant and anti-TNF blocker use rates were significantly higher in young group than other groups (log rank, p < 0.001).

Conclusion

Age at diagnosis according to Montreal classification is the important factor associated with prognosis of IBD. Diagnosis of IBD after age 40 years might be associated with better clinical outcomes.