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P619. The prevalence of anemia and its predictors in an out-patient cohort of IBD patients from a tertiary center

P. Zita1, T. Koller1, J. Toth1, M. Huorka1, Z. Zelinkova1, S. Oravcova1, T. Hlavaty1, 1University hospital Bratislava, Department of Gastroenterology and Hepatology, Bratislava, Slovakia

Background

Anemia is the most common complication of inflammatory bowel diseases (IBD). The prevalence of anemia varies from 17–68%. The aim of this study was to analyse the prevalence, severity and predictors of anemia in an out-patient IBD cohort.

Methods

The cohort consisted of 102 consecutive IBD patients, 57 Crohns disease (CD) and 45 patients with ulcerative colitis (UC) followed up in a tertiary IBD center in a period from September 1st to November 29th 2012. In every patient demographic, clinical characteristic and medication were recorded. Hemoglobin level, serum concentrations of iron, ferritin, CRP were established. Anaemia was defined as Hb <120 g/L in females and Hb <130 g/L in males. We analysed the prevalence of anemia and its predictors.

Results

The prevalence of anemia in a cohort of IBD patients was 26.5% (27/102). Severe anemia (Hb <80 g/L) was present in 1/102 (0.98%), moderate (Hb 80–100 g/L) in 2/102 (1.97%), and mild anemia in 24/102 (23.52%) IBD patients. There was no significant difference in anemia prevalence between CD 14/57 (24.6%) and UC 13/45 (28.9%). There was a trend for significance for the occurrence of anemia in UC pancolitis 7/17 (41.2%) in comparison with leftside colitis/proctitis vs. 5/26 (19.2%) (p = 0.11). Ileal involvement in CD was associated with a significantly higher rate of anemia in 14/46 (30.4%) patients as compared to colonic location 0/11 (0%), p = 0.008. We observed no association with AZA or other medication.

Conclusion

The prevalence of anemia in an out-patient IBD cohort was relatively high. Anemia was associated with ileal involvment in CD, there was a trend towards significance in pancolitis in UC.