P639. Influence of extraintestinal manifestations in health-related quality of life in inflammatory bowel disease patients
M. Barreiro-de Acosta1, M. Iglesias-Rey1, A. Lorenzo1, J.E. Dominguez-Munoz1, 1University Hospital, Gastroenterology, Santiago, Spain
Inflammatory bowel diseases (IBD) for Crohn's disease (CD) as well as ulcerative colitis (UC) patients are frequently associated with extraintestinal manifestations (EIM). The aim of this study was to assess if the presence of EIM was associated with a worse health-related quality of life (HRQOL) in IBD patients regardless of the activity of the disease.
A cross-sectional, prospective study with consecutive patient recruitment was designed. All adult patients with IBD who attended our IBD Unit were consecutively included. Patients were examined for the main reactive and non-reactive EIM of IBD. Reactive conditions were defined as those related to acute gut inflammation, i.e. dermatologic lesions, major eye complications and peripheral osteoarthritis. Associated non-reactive conditions were those unrelated to gut inflammation, such as ankylosing spondylitis, sacroileitis and sclerosing cholangitis. Remission was defined as a Harvey–Bradshaw score ≤4 for CD and as a Mayo score ≤2 in UC. To assess quality of life we used the IBDQ, which included five dimensions (Bowel Symptoms, Systemic Symptoms, Functional Impairment, Social Impairment, and Emotional Function). Total scores range from 36 to 252. We also used the SF-36 questionnaire, which included 8 scales (General Health, Physical Functioning, Role-Physical, Vitality, Role-Emotional, Social Functioning, Bodily Pain, and Mental Health). Total scores range from 0 to 100. In both cases, higher scores indicate better HRQOL. Results are shown as mean and standard deviation; the t-student test was used for comparing means.
799 patients were consecutively included, 323 (40.7%) CD; 470 (59.3%) UC, mean age of 44.63 years, range 18–81, 422 (52.8%) were female and 319 patients (39.8%) had a relapse. 159 patients (19.9%) presented any EIM. In all the dimensions of IBDQ questionnaire patients with EIM (mean 5.04) had worse quality of life than patients without EIM (mean 5.52), these differences being statistically significant (p < 0.001). Regarding SF-36 questionnaire, again in all scales, both physical and psychological, patients with EIM had significantly worse quality of life than patients without EIM (p < 0.001).
Patients with EIM, irrespective of the activity of the disease, have worse quality of life than those without EIM. The worse quality of life affects both physical and psychological aspects of the patients.
- Posted in: Poster presentations: Epidemiology (2013)