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P640. Inflammatory bowel disease demographic and clinical characteristics – findings from a tertiary care center in Romania

R. Zaharie1, V. Andreica1, A. Tantau1, F. Zaharie1, T. Mocan1, M. Tantau1, 1University of Medicine and Pharmacy Cluj-Napoca, Medicine-gastroenterology, Cluj-Napoca, Romania

Background

The aim of the study is to determine the clinical and demographic parameters of inflammatory bowel disease patients in a tertiary care center from Transilvania, Romania.

Methods

We included in the study IBD patients admitted between 1 January 2010 and 30 September 2012 in the Gastroenterology and Hepatology Institute Cluj-Napoca, Romania. Demographic and clinical features collected from the medical records were studied.

Results

A total of 220 IBD patients were included, 166 (74.5%) with ulcerative colitis, 54 (24.5%) with Crohn's disease. Mean age at diagnosis was 39.49 years. The male to female ratio was 1:2 in UC group and 1.6 in CD group. In both groups was observed the predominance of urban residence (68.67% in UC group, 75.92% in CD group, p: 0.310). A history of smoking was observed in 63% of CD patients and in 21% of UC patients (p < 0.005). In CD group the most frequent disease location was small intestine and the most frequent behavior was non-stricturing, non-penetrating. In the UC patient cohort, 21.08% had proctitis, 51.7% left-sided colitis, 9.63% extent colitis and 17.49% pancolitis and the evolutive pattern was chronic recurrent in 83.7% of patients, chronic continous in 13.3% and acute fulminant in 3% of US patients. The pseudomembranous colitis affected 3% from the UC group and none from the CD group. 6.6% from the UC patients and 50% from CD patients experienced intestinal complications (p < 0.005). Extraintestinal complications were more common in CD group (33%) compared with the UC group (13.33%) p = 0.001, with arthritis and erythema nodosum the most frequent. 38.2% from CD patients and 9.02% from UC underwent surgery for disease related complications.

Conclusion

The demographic pattern is similar to the one described before in the western European countries. Those diseases tend to cluster among urban communities affecting young individuals with higher education. The clinical course is different, with lower rates of intestinal and extraintestinal complications and lower need for surgery.