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P641. Health, marital and occupational state of patients with Crohn's disease relative to their non-IBD affected siblings and peers

C. Gratzer1, W. Reinisch1, H. Vogelsang1, C. Dejaco1, S. Angelberger1, A. Eser1, P. Christian1, P. Papay1, C. Urach2, A. Vavrovsky3, G. Novacek1, 1General Hospital Vienna, Gastroenterology, Vienna, Austria, 2Statistik Drahtwarenhandlung, Vienna, Austria, 3Academy for Value in Health GmbH, Vienna, Austria

Background

Health related quality of life (HRQoL), occupational and social life is impaired in patients with Crohn's disease (CD). Studies investigating the impact of CD on these components by direct comparison to non-IBD affected individuals from a similar environment are missing.

Methods

100 CD patients and 40 non-IBD affected controls, recruited by the patients from their social environment, i.e. siblings and friends were included. Social, economic and HRQoL data, assessed by SF-12 and EQ-5D were compared between both groups. CD specific predictors for impaired HRQoL, including disease activity, measured by Harvey Bradshaw Index, were delineated from logistic regression.

Results

Patients were more often unemployed (83% vs. 65%) and early retired (20% vs. 5%) than controls (p = 0.004). Physical (PCS 45.95±10.1 vs. 51.36±8.0) and mental (MCS 48.24±9.8 vs. 52.57±6.9) health of the SF-12 scored lower compared with controls (p = 0.02). EQ-5D identified impaired general health by EQ 5-D-VAS (71.4±21.5; 81.2±16.3; p = 0.01), as well as limitations through pain/ discomfort and in usual activities (p = 0.005). Disease activity was an independent risk factor for lower physical (OR 4.0; 95% CI: 2.3–8.9; p < 0.001) and mental (OR 2.7; 95% CI: 1.6–5.0; p < 0.001) scores. Furthermore smoking was identified to reduce MCS (OR 1.8; 95% CI: 0.6–6.0; p = 0.002). Patients with perianal disease were impaired in PCS (OR 3.4; 95% CI: 1.5–8.0; p = 0.003) with limitations in usual life and mobility (EQ-5D).

Conclusion

Our study points toward significant limitations in CD patients' lives compared to matched controls, i.e. siblings and peers.