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P664. Asthma prevalence in patients with inflammatory bowel disease

G. Sanchez-Sindin1, M. Barreiro-de Acosta2, M. Iglesias-Rey2, N. García Couceiro3, R. Ferreiro2, A. Lorenzo2, L. Valdes3, J.E. Dominguez-Munoz2, F.J. González-Barcala3, 1Hospital do Salnes, Emergency Department, Vilagarcia, Spain, 2University Hospital, Gastroenterology, Santiago, Spain, 3University Hospital, Respiratory, Santiago, Spain

Background

Inflammatory bowel diseases (IBD) are associated with a variety of extraintestinal manifestations, involving the respiratory system. The relation between IBD and asthma is not clear and whether it is an extraintestinal manifestation it is unknown. The aim of the study was to assess the prevalence of asthma in IBD patients.

Methods

A prospective study was designed. The case-studies all consisted of consecutive patients with IBD (Crohn's disease [CD] and ulcerative colitis [UC]) over 18 years of age who attended the monographic IBD unit for 6 months and who agreed to participate in the study. All were sent to the Respiratory department where the same protocol was performed. All patients completed the European Community Respiratory Health Survey (ECRHS) questionnaire. A spirometry with bronchodilator, a fractional exhaled nitric oxide (FeNO) test and a skin allergy test using the skin prick test method (SPT) were also performed. Probable asthma was considered as affirmative answer to one of the next questions of the ECRHS questionnaire: 1) Have you been woken by an attack of shortness of breath at any time in the last 12 months?; 2) Have you been woken by an attack of coughing at any time in the last 12 months?; 3) Have you woken up with a feeling of tightness in your chest at any time in the last 12 months?; 4) Have you had an attack of asthma in the last 12 months?; 5) Are you currently taking any medicines including inhalers, aerosols or tablets for asthma?. Confirmed asthma was diagnosed in cases with Probable asthma if values in the FeNO test were over 30 ppb or a change in the FEV1 was over 12% and 200 ml. Results are shown in percentages.

Results

132 patients were consecutively included, 53 (40.1%) CD; 79 (59.9%) UC, having a mean age of 45 years, ranging from 18 to 77, 65 (49.2%) being female. In UC more were men (59%) and in CD more were women (60%) (p = 0.03). Regarding asthma determination, 31 patients (23.5%) presented asthma symptoms in the ECRHS questionnaire. The prick test was positive in 31.3% of patients, the FeNO test was over 30 ppm in 24.1% of patients and a positive bronchodilator test was observed in 30.5% of patients. Overall we observed a probable asthma in 23.5% of all IBD patients and confirmed asthma in 16.9% of our sample. These figures are clearly higher than in an average population where asthma is present in around 5% of people.

Conclusion

Asthma prevalence seems to be high among our IBD patients, being superior to that of the average population.