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P666. A 7 years study on epidemiologic aspects of inflammatory bowel disease in the north east of Italy

T. Slongo1, R. Marcello1, F. Ferrara1, G. Battistella2, H. Heras Salvat1, G. Guarnieri1, N. Dal Bò1, S. Loperfido1, A. Caroli1, A. Schiavinato1, A. Furlanetto3, A.P. Dei Tos3, F. Di Mario1, 1Gastroenterology Unit, Treviso General Hospital, Department of Internal Medicine, Treviso, Italy, 2Treviso General Hospital, Department of Clinical Epidemiology, Treviso, Italy, 3Pathology Unit, Treviso General Hospital, Department of Clinical Pathology, Treviso, Italy

Background

Several studies confirm that the incidence and prevalence of inflammatory bowel disease (IBD) are increasing with time. Moreover the distribution of these results is extremely heterogeneous according to different geographic areas considered. Great interest causes this evaluation since the IBD are chronic diseases that require continuing therapy and assistance. It is not clear if the trend is justified by environmental risk factors or if it is secondary to a greater diagnostic accuracy. The aim of this study was to determine the change of prevalence of IBD, ulcerative colitis (UC) and Crohn's disease (CD), in the residing population in our Sanitary District 9 Veneto in the last seven years.

Methods

A retrospective study of prevalence was performed in an area on 500,000 inhabitants from 2005 to 2011 evaluating the IBD registry of the National Health System and considering all new registered exemptions.

Results

353 new exemptions for IBD have been reported during the observation period. The prevalence of IBD detected in 2005 was 100.36/100,000 inhabitants of which 25.46/100,000 CD and 74.89/100,000 UC; no statistically significant difference between males and females (p = ns). In 2011, however, the prevalence of IBD was 179.13/100,000 inhabitants of which 59.63/100,000 CD and 119.5/100,000 UC, being the male population higher than the female one (p = 0.028). In a cohort of 398 cases followed for 5 years no difference in the average age of death in comparison to the general population was found (IBD men 72.1±16.6 yrs, women 79.3±10.2 yrs vs general population men 74.2±16 yrs, women 81.2±15 yrs, p = ns). The most frequent cause of death is represented by cardiovascular disease (8 cases), followed by cancers not related to IBD (6 cases), other (3 cases). One patient died of complications related to UC diagnosed in late age.

Conclusion

The prevalence rate of IBD in the studied district corresponds to the data detected in the countries of northern Europe. A progressive increase in the diagnosis of IBD in the last years has been demonstrated, namely 179/100,000 inhabitants in 2011 opposite to 100/100,000 at baseline (2005). At the same time, leasting the years CD increased from 25/100,000 to 56/1000.000. The life expectancy in IBD is similar to that of the general population and the causes of death are not related to IBD.