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P100. Vitamin D in patients with Crohn's disease

V. Teixeira1, S. Velho1, J. Torres2, L. Glória2, M. Cravo2, 1Hospital Beatriz Ângelo, Serviço de Dietética e Nutrição, Lisboa, Portugal, 2Hospital Beatriz Ângelo, Serviço de Gastrenterologia, Lisboa, Portugal

Background

Traditionally vitamin D has been associated to bone health; however, in patients with Crohn's disease (CD), it has also been hypothesized that the vitamin D axis may play an important role in muscle strength and regulation of immune response. In addition, single-nucleotide polymorphisms in the vitamin D receptor seem to be associated to a higher susceptibility to CD. The aim of our study was to investigate 25-hydroxy-vitamin-D3 [25(OH)D3] status and to identify independent predictors of serum 25(OH)D3 in patients with CD.

Methods

We conducted a cross-sectional study which included 41 patients with CD. Clinical data (gender, age, disease duration, Harvey–Bradshaw Index, disease location and phenotype) and life style variables (sun exposure, physical activity, multivitamin supplements intake and smoking habits) were collected during interview with the enrolled patients. Data concerning anthropometric measures (weight, height, Body Mass Index, arm and waist circumference), dietary intake (assessed with a Semi-Quantitative Food Frequency Questionnaire) and nutritional status (assessed with Subjective Global Assessment Questionnaire) were also recorded. Serum 25(OH)D was measured in 21 subjects. Data analysis was performed with SPSS 20 (IBM statistics SPSS) and R software.

Results

Suboptimal 25(OH)D3 serum levels were observed in 90% (n = 19) of subjects, whereas serious deficit was found in 57.1% (n = 12) and low levels of 25(OH)D3 in 33.3% (n = 7) of CD patients. No significant association was found between mean serum levels of 25(OH)D3 and gender, disease location, phenotype, disease activity, multivitamin supplements intake, physical activity, smoking habits, BMI, vitamin D intake or sun exposure. A significant difference in mean serum 25(OH)D3 was found in patients who had been operated (previous surgery: 17.1±3.6; no surgery: 26.3±7.47, p = 0.003). A significant inverse relationship was found between serum 25(OH)D3 and age (−0.545; p = 0.011) and disease duration (r = −0.501; p = 0.021). In multivariate analysis only the negative relationship between serum 25(OH)D3 and age (β = −0.24; p = 0.0194) remained significant; disease duration and previous surgery were no longer statistically significant after adjustment for age, disease activity, vitamin D intake and smoking habits.

Conclusion

Deficiency of 25(OH)D was found to be highly prevalent in the enrolled patients with CD. The main independent predictor of serum 25(OH)D identified in our study was age.