P104. Usefulness of measurement of serum procalcitonin level in patients with inflammatory bowel diseases
S. Chung1, H.W. Lee2, S.W. Kim2, S.J. Park2, S.P. Hong2, T.I. Kim2, W.H. Kim2, J.H. Cheon2, 1Ajou Medical University, Internal Medicine, Suwon, South Korea, 2Yonsei University College of Medicine, Internal Medicine, Seoul, South Korea
Serum procalcitonin level is known to be elevated in various infectious and noninfectious diseases. However, relationships between serum procalcitonin level and infectious status and/or disease activity in inflammatory bowel diseases have yet to be determined. We compared serum procalcitonin level in infectious and noninfectious states of patients with inflammatory bowel diseases. We also investigated the relationships between disease activity of inflammatory bowel disease and serum procalcitonin level.
We retrospectively analyzed the clinical data and endoscopic data of a total of 85 patients with inflammatory bowel diseases in whom serum procalcitonin levels were measured between Jan. 2005 and Feb. 2013.
The mean serum procalcitonin levels in inflammatory bowel disease patients with sepsis (N = 8), those with infection but without sepsis (N = 37), and those without infection (N = 40) were 17.3±20.6 ng/ml, 1.8±3.9 ng/ml, and 1.3±4.5 ng/ml, respectively (P < 0.001). In patients with ulcerative colitis or Crohn's disease, serum procalcitonin levels were not different according to disease location or disease activity. In patients with intestinal Behçet's disease, serum procalcitonin levels in patients with active disease were significantly higher than those with quiescent state (4.9±12.0 ng/ml vs. 0.3±0.7 ng/ml, P = 0.03). In the correlation analysis, serum procalcitonin level and disease activity index for intestinal Behçet's disease had a moderate correlation (Spearman correlation coefficient: 0.434, P = 0.01).
Measurement of serum procalcitonin level was useful in differentiating patients with infectious complications and those without in inflammatory bowel diseases. Moreover, in patients with intestinal Behçet's disease, serum procalcitonin level had a moderate positive relationship with disease activity. Therefore, serum procalcitonin level could be a candidate biomarker for estimating infectious state in inflammatory bowel diseases and disease activity in intestinal Behçet's disease.