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P115. The influence of maternal IBD on childbirth and further development of children

L. Stoehr1, B. Bokemeyer2, C. Buening3, A. Dignass4, U. Helwig5, I. Koenig6, C. Maaser7, M. Mross8, J. Mudter9, T. Ochsenkuehn10, B. Siegmund11, N. Teich12, A. Sturm13, A. Schirbel1, 1Charite, Hepatology and Gastroenterology Campus Virchow Klinikum, Berlin, Germany, 2Gastroenterology Practice Minden, Gastroenterology, Minden, Germany, 3Charite, Hepatology and Gastroenterology Campus Mitte, Berlin, Germany, 4Markus Krankenhaus, Internal Medicine, Frankfurt/Main, Germany, 5Gastroenterology Practice Oldenburg, Gastroenterology, Oldenburg, Germany, 6Gastroenterology Practice Bautzen, Gastroenterology, Bautzen, Germany, 7Klinikum Lueneburg, Internal Medicine and Gastroenterology, Lueneburg, Germany, 8Gastroenterology Practice Berlin, Gastroenterology, Berlin, Germany, 9University Erlangen, Medizinische Klinik I, Erlangen, Germany, 10Universität München, Klinikum Großhadern, Medizinische Klinik II, Muenchen, Germany, 11Charite, Hepatology and Gastroenterology Campus Benjamin Franklin, Berlin, Germany, 12Gastroenterology Practice Leipzig, Gastroenterology, Leipzig, Germany, 13Krankenhaus Waldfriede, Gastroenterology, Berlin, Germany

Background

It is well known that children of mothers with IBD have a lower birth weight and height compared to the general population. Nevertheless, there are only limited data on the further development of those children. Therefore, we aimed to analyze the development of children of mothers with IBD including possible risk factors for their delayed development.

Methods

55 IBD mothers and their firstborn children from IBD outpatient clinics of german University Hospitals or from medical practices, specialized in IBD were included. Control population was analyzed using the German Perinatal Survey and the German Health Interview and Examination Survey for Children and Adolescents (KIGGS) performed by the Robert Koch Institute (n = 17641). We used a specifically designed questionnaire in addition to the well established questionnaires for the preventive medical checkups for children (U1-birth, U8-4 years, U9-5 years). Statistical analyses were performed using SPSS 20.0.

Results

We confirmed that the incidence of low birth weight (3052g vs. 3387g, p < 0.0001) and low birth height (49.2cm vs. 50.5cm, p < 0.001) are significantly higher among children of mothers with IBD compared to the general population. Furthermore, children of mothers with IBD at the age of 4 years were still significantly lighter (p = 0.024) and smaller (p = 0.003) compared to controls. Interestingly, at the age of 5 years there was no significant difference between the groups regarding weight (20.2 kg vs. 20.6 kg, p = 0.54) or height (113cm vs. 114.6cm, p = 0.16) anymore. Although, the BMI of children of mothers with ulcerative colitis was significantly lower at the age of 5 years compared to children of mothers with Crohn's Disease (p = 0.009), there was no significant difference between Crohn's disease or ulcerative colitis regarding height or weight of children at any time point. In addition, there was no significant difference regarding the head circumference at any time point.

Interestingly, there was no influence of the disease duration of the mother on any of the analyzed parameters. Furthermore, the sex of children had no influence on any parameter. In IBD mothers 34.5% had C-section compared to 31.9% in the general german population. Significantly more children of IBD mothers were pre-term born compared to the general population (28.3% vs. 9.2%). There was no influence of disease duration on rate of pre-term birth.

Conclusion

Despite the lower birth weight and height of children of IBD mothers the further development of those children tend to catch up on their “healthy” contemporaries at the age of 5 years. Based on these information we should encourage our patients to raise their own family.