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P130. The prevalence of iron deficiency and anemia in an IBD referral center in Serbia

V. Gligorijevic, D. Bojic, S. Markovic, B. Maksimovic, G. Gligorijevic, N. Jojic, University Clinical-Hospital Centre “Zvezdara”, Gastroenterology and Hepatology Department, Belgrade, Serbia

Background

Anemia is one of most frequent complication in inflammatory bowel diseases (IBD). Most patients have iron deficiency (ID) as a consequence of intestinal bleeding, inflammation and malapsorption. Types of anemia are: iron deficiency anemia (IDA), anemia of chronic disease (ACD) and anemia of mixed origin (AMO). Anemia have significant impact on the quality of life (QoL) of this patients and correction is very important. Oral iron treatment is limited mostly by poor iron absorption. Combination therapy with IV iron and erythropoetin showest highest efficacy.

Methods

Aim was to evaluate the prevalence of ID and types of anemia among hospitalized IBD patients in our referral IBD Center, during oct/2012.-oct/2013. IDA was defined as decreased serum iron (<10 ng/mL), transferrin saturation and ferritin level (<30 ng/mL) and normal CRP; ACD was defined as decreased serum iron and transferrin saturation also, but increased ferritin level (>100 ng/mL) and CRP. AMO was defined as decreased serum iron and serum transferrin, normal ferritin level and increased CRP. The Fischer test performed for statistical analyses.

Results

Among 155 hospitalized IBD patients (105/68% CD and 50/32% UC) female/male ratio was 2:1. Median age at diagnosis was 28±1 in CD, and 39±2 in UC. Median duration of diseses was 10±4 in CD group and 12±3 in UC. Disease localisation in CD was: 18% ileitis, 47% ileocolitis and 37% colitis. In UC 50% had extensive colitis, 65% distal colitis and 10% proctitis. Overall prevalence of anemija in IBD patients was 67.6%. In CD group IDA was found in 27%, ACD in 9% and AMO in 9%. In UC patients 32% had IDA, ACE was found in 6% and AMO in 8%. In spite of significantly more frequent rectal bleeding in UC group (p < 0.0001), there was no significant difference in IDA occurence between UC and CD patients (p = 0.5).

Conclusion

Two thirds of IBD patients with long disease duration had anemia. IDA is the most common type of anemia diagnosed in one third of CD and UC patients.