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P135. Sleep disorders in inflammatory bowel disease: incidence and use of ambulatory polysomnography

A. Shitrit1, C. Chen Shuali2, B. Koslowsky1, T. Adar1, S. Shteingart1, E. Goldin1, 1Shaare Zedek Medical Center, Digestive diseases institute, Jerusalem, Israel, 2Shaare Zedek Medical Center, Internal Medicine, Jerusalem, Israel

Background

Fatigue and sleep disturbances are common in patients with inflammatory bowel Disease (IBD) and may precipitate exacerbations of IBD. However, little is known about the pattern and the specific correlations between these sleep disturbances in IBD patients.

Methods

A prospective study was conducted and included 38 stable IBD patients and 27 matched controls. Harvey–Bradshaw (HBS) and partial Mayo scores were calculated for Crohn's disease and ulcerative colitis patients, respectively. IBD patients with HBS above 8 or partial Mayo above 4 were excluded. All patients underwent overnight ambulatory polysomnography using a Watch PAT, a portable diagnostic system that measures the phases of sleep and apnea indices, including: Respiratory Disturbance Index (RDI), Apnea-Hypopnea Index (AHI) and Oxygen Desaturation Index (ODI).

Results

34 IBD patients and 27 matched controls completed the study. The control weighed more than the patients group (73 kg vs. 63, p = 0.02). The IBD group had a significantly lower percentage of REM sleep (23% vs. 27%, P = 0.039). No statistically significant differences were found in terms of RDI and ODI. However, among the IBD group, when comparing the sleep indexes to activity scores, the IBD patients with more active disease had more desaturation events (p = 0.03).

Conclusion

Stable IBD patients have less REM sleep than healthy controls. Active disease correlates with more sleep disturbances. These findings may explain some of the reasons for the common fatigue among IBD patients. Further large studies are needed to characterize the sleep disturbances among these patients.