Search in the Abstract Database

Abstracts Search 2014

* = Presenting author

P137. Sexual dysfunction in inflammatory bowel disease patients

O. Yanartas1, H.T. Kani2, M. Banzragch3, E. Bicakci3, A. Sakalli Kani4, O. Atug3, K. Kuscu1, N. Imeryuz3, H. Akin3, 1Marmara University, School of Medicine, Psychiatry, Istanbul, Turkey, 2Marmara University, School of Medicine, Internal Medicine, Istanbul, Turkey, 3Marmara University, School of Medicine, Gastroenterology, Istanbul, Turkey, 4Istanbul University Cerrahpasa Medical Faculty, Psychiatry, Istanbul, Turkey

Background

Sexual dysfunction (SD) in Inflammatory Bowel Disease (IBD) has a complex background and influences on the quality of life. Our aim was to determine the frequency and the characteristics of SD and its' relation with Quality of Life (QoL), anxiety and depression in IBD patients.

Methods

Patients asked to answer 3 self-report questionnaires in outpatient clinics between May and November 2013. Hospital Anxiety and Depression (HAD) scale has 2 seperate parts; risk of anxiety and depression. Arizona Sexual Experience Scale (ASEX) has subgroups as desire, arousal, penile erection/vaginal lubrication, ability to reach orgasm and satisfaction. Short Form-36 (SF-36) is used for QoL. Crohn's Disease Activity Index (CDAI), Modified Mayo Score (MMS), Truelove–Witts score (TWS) and demographic data were collected.

Results

A total of 177 IBD patients included. Mean age was 40.8±12.7 years. 99 (56%) were female, 80 (45%) Crohn's Disease (CD) and 97 (55%) were Ulcerative Colitis (UC). Demographic data of UC and CD groups were statistically similar. Mean MMS, TWS and CDAI were 2.4, 2.4, 130 respectively. All scores of ASEX were significantly worse in CD patients compared to UC patients (p = 0.001). ASEX scores were similar in the female patients of CD vs UC statistically. Male patients' ASEX scores of CD were worse than UC male patients (p = 0.04). In CD, UC and all patient groups ASEX scores were significantly worse in female patients then male patients (p = 0.002, 0.0001, 0.0001 respectively). QoL were statistically worse in female patients in all subitems (p < 0.05) compared to male patients. Females had worse scores in all subitems of SF-36. Female patients' anxiety subscores of HAD were significantly worse (p = 0.005) compared to male. There was no difference in depression subscore (male vs female).

Table 1 (abstract P137): Comparison of patients according to questionnaires' subitems
All patientsCrohn's diseaseUlcerative colitisFemale patientsMale patients
FemaleMalepFemaleMalepFemaleMalepCDUCpCDUCp
SF-36 (mean values)
Physical functioning60.2679.090.0001*59.7082.880.001*60.9076.950.009*59.7060.900.8382.8876.950.38
Role physical41.8459.370.011*46.5664.420.08836.3656.520.032*46.5636.360.2464.4256.520.47
Bodily pain51.5666.770.0001*52.1962.070.1150.8369.430.001*52.1950.830.7862.0769.430.25
General health37.0650.800.0001*34.8849.960.009*39.5951.280.029*34.8839.590.3349.9651.280.83
Vitality45.7357.220.003*44.6051.920.247.0460.210.013*44.6047.040.6351.9260.210.16
Social functioning53.6864.580.011*55.1465.380.1351.9864.130.035*55.1451.980.5465.3864.130.86
Role emotional41.4058.330.025*39.8658.970.1543.1857.960.139.8643.180.7458.9757.960.93
Mental health51.8760.110.014*52.0054.920.5651.7263.040.014*52.0051.720.9554.9263.040.1
ASEX (mean values)
Desire3.662.630.0001*3.723.080.05*3.582.40.0001*3.723.580.613.082.40.02*
Excitement3.782.70.0001*3.953.080.01*3.542.50.0001*3.953.540.173.082.50.06*
Penile erection/Vaginal lubrication3.452.520.0001*3.622.920.037*3.22.310.004*3.623.200.182.922.310.052
Ability to reach orgasm3.782.470.0001*3.972.540.0001*3.512.430.0001*3.973.510.142.542.430.06
Satisfaction from orgasm3.262.20.0001*3.412.480.02*3.032.040.0001*3.413.030.312.482.040.11
Sexual dysfunction17.8112.480.0001*18.6513.950.002*16.5711.690.0001*18.6516.570.1413.9511.690.04*
HAD (mean values)
Anxiety9.047.030.005*9.177.920.248.896.580.022*9.178.890.777.926.580.22
Depression7.536.420.17.786.850.387.226.210.267.787.220.536.856.210.56
*P values <0.05, statistically significant. CD, Crohn's disease; UC, Ulcerative colitis.

Conclusion

CDAI positively correlated with HAD and ASEX whereas negatively correlated with SF-36 significantly. TWS was also positively correlated with depression subitem of HAD, and negative correlated with all subitems of SF-36 significantly. SD positively correlated with disease activity indexes both in CD and UC. Male CD patients had significantly higher SD compared to UC male patients but there was no difference between female CD and female UC. Also female patients in CD, UC and the whole group were statistically worse compared to male patients in all items of SD, QoL and also anxiety subscore of HAD. Worse scores in females may be due to lower women socioeconomic levels of women in our hospital region. Major limitation of this study is the absence of control group.