P146. Role of fecal neutrophil gelatinase-associated lipocalin assessment in patients with inflammatory bowel disease
D. Mukhametova1, D. Abdulganieva1, O. Zinkevich2, N. Saphina2, A. Odintsova3, M. Koporulina2, 1Kazan State Medical University, Hospital Therapy, Kazan, Russian Federation, 2Kazan State Medical Academy, Central Research Laboratory, Kazan, Russian Federation, 3Republican Clinical Hospital, Department of Gastroenterology, Kazan, Russian Federation
Neutrophil gelatinase-associated lipocalin (NGAL) is known as a marker of intestinal inflammation.
Aim: To evaluate the fecal concentration of NGAL in different courses of inflammatory bowel disease (IBD).
We prospectively included 33 patients with IBD exacerbation [11 pts with Crohn's disease (CD) and 22 pts with ulcerative colitis (UC)] and 11 healthy volunteers. The concentration of NGAL in faeces was determined by enzyme immunoassay. The average age of patients with CD was 40.9±4.2 years, UC - 40.7±11.3 years, in the control group - 31.1±3.6 years. Severity of UC was assessed by Mayo score: mild UC was seen in 4 (18.2%), moderate - 12 (54.5%), severe - 6 (27.3%), in CD by CDAI: mild - 1 (9%), moderate - 5 (45.5%), severe - 5 (45.5%).
Fecal NGAL level was increased in both UC and CD exacerbation. In active CD [mean 5924.27±2067.6 ng/ml] (p < 0.01) and UC [mean 5826.09±891.8 ng/ml] (p < 0.001) NGAL levels were higher than in the control group [mean 658.8±237.7 ng/ml].
Concentration of fecal NGAL correlated with the severity of CD: in severe attacks NGAL level were increased (r = 0.74; p = 0.008), in UC we observed only tendency. Also in CD NGAL levels had a significant correlation with the C-reactive protein (r = 0.77; p = 0.04), as well as with some clinical features - the severity of fever (r = 0.75; p < 0.05), in UC we didn't found any correlations.
The fecal concentration of neutrophil gelatinase-associated lipocalin significantly increased during flare of IBD. The concentration of NGAL was more informative in CD - correlated with the severity and activity of CD.