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P180. Non-invasive assessment of cardiovascular risk in young patients with inflammatory bowel disease (IBD) compared with healthy controls (HC)

M. Cappello1, I. Bravatà1, A. Aiello1, V. Calvaruso1, D. Torres2, A. Tuttolomondo2, A. Licata1, A. Craxì1, C. Cammà1, 1University of Palermo, Gastroenterology Section, DiBiMis, Palermo, Italy, 2University of Palermo, Internal Medicine and Cardioangiology Section, DiBiMis, Palermo, Italy

Background

Recent studies have documented an increased cardiovascular risk in IBD patients. Our study aimed at investigating the prevalence of intima-media thickness (IMT) of the carotid arteries and of the arterial stiffness indices as signs of early atherosclerosis in young patients with IBD.

Methods

We recruited 68 consecutive IBD patients (35 males), and 38 sex and age matched HC. Median age was 31.6±8.1 years. Data on clinical and demographic features, cardiovascular risk factors, personal and familial history of cardiovascular events, concomitant therapies were registered on a dedicate database. Forty-five out of IBD patients had Crohn's disease (CD) and 23 had Ulcerative Colitis (UC). Twenty-two CD patients had a disease duration greater than 5 years and 9 showed a clinically active disease. In the UC group 8 patients had a disease duration greater than 5 years and 3 clinically active disease. Sixteen out of 68 IBD patients were smokers, 9 ex-smokers; 29 had a family history of cardiovascular events, 3 were hypertensive and 2 patients had diabetes mellitus, 21 had a BMI greater than 25. Left and right carotid IMT was evaluated using high resolution B-mode ultrasonography. Arterial stiffness was assessed by measurement of carotid-femoral Pulse Wave Velocity (PWV) and Augmentation Index (AI).

Results

there was a statistically significant difference between IBD patients and HC for total cholesterol values (P < 0.013) and LDL-cholesterol (P < 0.019). There was no difference in lipid profile between CD and UC. Overall, there was a trend toward significance in the distribution of BMI values between patients and HC (P 0.082). Right carotid IMT was higher in IBD group than in controls (P < 0.047), but there was no statistically significant difference between subjects with CD and UC. Moreover, PWV average and AORTIC AIX (AIx) were significantly higher in patients than in controls (P < 0.006 and P < 0.004 respectively).

Conclusion

In our study we have found signs of early onset ATS in young patients with IBD. Therefore, clinical follow-up of IBD patients should include assessment at diagnosis and monitoring of IMT of the carotid arteries and of the arterial stiffness in order to reduce the risk of cardiovascular events.