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P208. Ileal wall thickness detected by MSCTE predicts the disease severity of Crohn's disease

X. Yang, L. Yu, Z. Liu, Shanghai Tenth People's Hospital, Tongji University, Department of Gastroenterology, Shanghai, China

Background

Multidetector spiral computed tomography enterography (MSCTE) and ileocolonoscopy are used to evaluate inflammatory situation of Crohn's disease (CD) patients. The purpose of this study was to determine the disease severity of CD patients by combining the wall thickness by MSCTE with ileocolonoscopy.

Methods

This retrospective study included 50 patients with terminal ileal CD. Diagnosis was confirmed based on clinical features, endoscopy and pathology. Patients were underwent both MSCTE and ileocolonoscopy. Ileal wall thickness was measured, and the disease severity was evaluated by the Crohn's disease activity index (CDAI). Intestinal mucosal lesions were scored by the Simple Endoscopic Score for Crohn's Disease (SES-CD).

Results

Of 50 patients with active terminal ileal CD, the comparison of scores between SES-CD and CDAI showed significant association with Spearman's rank correlation coefficient (P < 0.01). There was statistically significant correlation between the wall thickness and SES-CD (P < 0.0001) as well as CDAI (P < 0.001), respectively, but no significant correlation between the wall thickness and the C-reactive protein (CRP) was found (P = 0.43). Moreover, we found that the wall thickness was preferential to predict the disease severity in the terminal ileal CD.

Conclusion

MSCTE, in combination with ileocolonoscopy, is reliable to identify the disease severity in CD patients, and provides more accurate approach in the diagnosis and treatment.