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P226. Evaluation of intestinal permeability on the basis of zonulin levels, in children with inflammatory bowel disease

U. Chlebowczyk1, D. Pabijasz2, S. Wiecek1, H. Wos1, 1Medical University of Silesia, Department of Pediatrics, Gastroenterology Unit, Katowice, Poland, 2Upper-Silesian Child Health Care Centre Katowice, Poland, Department of Pediatrics, Katowice, Poland

Background

Inflammatory bowel disease in children is often associated with other autoimmune disorders. An abdominal pain, weight loss and growth disturbance occur in celiac disease, food allergies and also in IBD. In the pathogenesis of these diseases, the impact of increased intestinal permeability is considered.

The aim of the study is estimation of incidence of celiac disease and food allergy in children with inflammatory bowel disease and determination of their correlation with the serum zonulin levels.

Methods

The analysis included 71 children in age from 4 to 18 years with the active Crohn's disease and ulcerative colitis. The control group consisted of 32 children in the same age range without gastrointestinal symptoms. In the group of examined children immunological tests to diagnose celiac disease and food allergy were performed. In all children, quantitative determination of zonulin in serum was made.

Results

In the examined group of patients with inflammatory bowel disease celiac disease has not occurred. In both groups, in more than half of children, elevated total IgE values occurred and in the case of atopic, increased zonulin levels and significantly positive correlation between serum zonulin and total IgE was found.

Conclusion

Increased zonulin levels in children with atopic in the course of inflammatory bowel disease confirm its role as a biomarker of intestinal permeability. In the future, measurement of its levels in children with inflammatory bowel disease may also be one of non-invasive tests used in practice in the evaluation of the intestinal mucosa.