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P228. Evaluation of the correlation between serum levels of hepcidin and disease activity in inflammatory bowel diseases

Z.B. Paköz, C. Çekiç, E.S. Yüksel, S. Vatansever, M. Arabul, B. Unsal, Katip Çelebi University, Atatürk Training and Research Hospital, Gastroenterology, Izmir, Turkey

Background

Although many serological markers have been defined for inflammatory bowel disease (IBD), there is limited evidence that affect the clinical outcomes. This study aims to evaluate the correlation between serum levels of hepcidin and disease activity in IBD.

Methods

The study included 52 patients with ulcerative colitis (UC) and 33 patients with Crohn's disease (CD). Serum levels of hepcidin were determined using ELISA method. Hepcidin levels and disease activity, interleukin-6 (IL-6) and C-reactive protein (CRP) levels were compared.

Results

Mean serum levels of hepcidin in CD in remission and in active stage were respectively 3837±1436 pg/ml and 3752±1274 pg/ml and no significant correlation was found between disease activity and hepcidin levels (p = 0.613). Mean serum levels of hepcidin in UC in remission and in active stage were respectively 4285±8623 pg/ml and 3727±1176 pg/ml and no significant correlation was found between disease activity and hepcidin levels (p = 0.241). In the correlation analysis between inflammatory markers and serum levels of hepcidin, no correlation was found between hepcidin levels and IL-6 (p = 0.582) and CRP (p = 0.783).

Conclusion

In this study, no significant correlation was detected between serum levels of hepcidin and disease activity in IBD. Serum levels of hepcidin were seen to be inconsistent with IL-6 and CRP levels.