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P276. Association between serum 25-hydroxy vitamin D concentration and inflammatory bowel disease characteristics in North-Eastern Romania

G. Dumitrescu, C. Mihai, M. Dranga, C. Cijevschi Prelipcean, University of Medicine and Pharmacy “Gr. T. Popa”, Iasi, Institute of Gastroenterology and Hepatology, Iasi, Romania

Background

A vitamin D deficiency has been found in patients with inflammatory bowel disease (IBD) in many countries of Western Europe, whereas in Eastern European countries, data are poorly reported.

Aim: To describe the relationship between the vitamin D level and IBD characteristics in North-Eastern Romanian patients with IBD.

Methods

This prospective monocentric study was conducted between March 2011 and June 2012 and included consecutive IBD patients seen in The Institute of Gastroenterology and Hepatology Iasi, Romania who were age- and gender-matched with a group of healthy subjects from the same geographic region. Diagnosis of IBD was established based on endoscopic, histological and radiological findings. Demographic data, disease characteristics, ongoing treatments and biological parameters were recorded. Vitamin D level was defined as sufficient >30 ng/ml, insufficient 20–30 ng/ml or severely deficient <20 ng/ml.

Results

Forty-seven IBD patients were included in this study: 33 had ulcerative colitis (UC) and 14 had Crohn's disease (CD). Only 24% of UC patients and 21% of CD patients had sufficient vitamin D levels. The vitamin D level was significantly lower in CD patients with moderate to severe disease activity than in patients in remission or with mild activity (16±6 vs 26±7 vs 31±9, p = 0.02). The vitamin D level in UC patients was not influenced by the disease activity and no correlation was observed between inflammation markers and the vitamin D level. No association was observed between the vitamin D level and the smoking status (p = 0.69) or the ongoing medication (p = 0.56 for 5ASA, p = 0.84 for steroids, p = 0.69 for anti-TNF-alpha). Newly diagnosed IBD patients had lower vitamin D levels than the others (22±9 vs 26±12, p = 0.86 for UC patients, and 18±6 vs 27±11, p = 0.22 for CD patients). No association was found between the season during which the visit was scheduled and the vitamin D level although UC patients evaluated during the winter had lower levels than those evaluated during the summer (22±9 vs 28±13, p = 0.31).

Conclusion

The vitamin D deficiency is common in IBD patients in North-Eastern Romania. CD patients with moderate to severe activity had a significantly lower vitamin D levels.