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P476. Gender specific differences in quality of life in Danish paediatric patients with inflammatory bowel disease

K. Carlsen1,2, C. Jakobsen1, L.F. Hansen1, A. Paerregaard1, V. Wewer1, P. Munkholm2, 1Copenhagen University Hospital, Department of Paediatrics, Hvidovre, Denmark, 2Copenhagen University Hospital, Department of Gastroenterology, Herlev, Denmark

Background

IMPACT III is a validated health-related Quality of Life (QoL) questionnaire for paediatric patients with Inflammatory Bowel Disease (IBD) aged 10–17 years in English language. The questionnaire consists of 35 questions with a 5 point Likert scale ranging from 1–5 and a higher score represents better QoL (min 35, max 175). The questions are divided into 6 domains: Bowel symptoms, Systemic symptoms, Emotional functioning, Social functioning, Body image and Treatments. The objective of this study was to translate IMPACT III into Danish and evaluate QoL in Danish paediatric patients aged 10–17 years.

Methods

Through cooperation with the “Paediatric Inflammatory Bowel Disease Working Group on Quality of Life” the IMPACT III questionnaire was translated to Danish using a cross-cultural adaptation by a forward-backward translation and cognitive debriefing.

To evaluate QoL, random IBD patients aged 10–17 years in the out-patient clinic were asked to answer the IMPACT III questionnaire. Associations between the IMPACT III score and the following data were analysed by a general linear model: gender, age, diagnosis [Crohn's disease (CD)/ulcerative colitis (UC)], treatment (tablets e.g. 5-ASA, azathiopurine, prednisolone or intravenous biologicals; Infliximab), age at diagnosis, disease duration and disease activity registered by paediatric IBD-symptom score (abbPCDAI and PUCAI).

Results

54 patients were included. Characteristics: female/male 27/27; mean age 15.1 years (SD 2.1);CD/UC 27/27; treatment tablets/biologicals 28/26; mean age at diagnosis 12.5 years (SD 2.4); mean disease duration 2.7 years (SD 1.6); disease activity (merged aPCDAI and PUCAI) inactive n = 19, mild n = 22, moderate n = 3, severe n = 0 (missed data n = 10). Mean IMPACT III score of Danish IBD patients aged 10–17 years was 150.8 (SD 11.0).

A significantly better QoL (p = 0.038) was found in males (mean 153.9 SD 9.3) compared to females (mean 147.7 SD 11.9). Regarding domains, Body image and Emotional functioning were significantly higher in males (p = 0.46 and p = 0.002). A significantly better QoL (p = 0.019) was seen in patients with inactive disease (mean 152.1 SD 13.1) compared to active disease (mean 135 SD 1.7). A higher QoL in patients with inactive disease was found in following domains: Bowel symptoms (P = 0.019), Social functioning (p = 0.016) and Body image (p = 0.045). No significant differences in QoL were found for the variables: age, diagnosis, treatment, age at diagnosis and disease duration.

Conclusion

IMPACT III is now available in Danish language. Female IBD patients aged 10–17 years seems to have a lower QoL compared with males in same age group. Disease activity significantly influences patients perception of QoL.