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P527. Correlation between the Crohn's Disease Activity Index and a web-based self-reporting symptoms diary of Crohn's disease

E.S. Kim1, K.B. Cho1, K.S. Park1, B.I. Jang2, K.O. Kim2, E.Y. Kim3, S.W. Jeon4, M.K. Jung4, C.H. Yang5, 1Keimyung University School of Medicine, Internal Medicine, Daegu, Korea, Republic of, 2Yeungnam University College of Medicine, Internal Medicine, Daegu, Korea, Republic of, 3Catholic University of Daegu School of Medicine, Internal Medicine, Daegu, Korea, Republic of, 4Kyungpook National University School of Medicine, Internal Medicine, Daegu, Korea, Republic of, 5Dongguk University College of Medicine, Division of gastroenterology and Hepatology, department of Internal Medicine, Kyungju, Korea, Republic of

Background

Crohn's Disease Acitivity Index (CDAI) is known to be complex, time-consuming, and impractical. The aim of this study was to investigate whether a newly-developed, simple web-based self-reporting symptoms diary of CD (CDSD) was equally effective in assessing disease severity.

Methods

CDSD consisted of 5 clinical items (general well being, abdominal pain, number of liquid stools, abdominal mass, and complications) which could be easily recorded through online web site (www.CDSD.or.kr). Images were inserted to help patients better understand the complications. All patients were asked to visit and record their symptoms on weekly bases. CDAI and CDSD were recorded on patients visit to the hospitals. Data were analyzed to determine if scores from the CDAI correlated with those from the CDSD for defining disease remission.

Results

Analysis of 288 data pairs showed a positive correlation between scores. The correlation between the systems was 0.673 (Spearman correlation coefficient). Through ROC curve, the score ≤5 points of CDSD was identified to correspond to a CDAI score ≤150 points (clinical remission). Using cutoff value 5 points of CDSD, the positive and negative predictive value for the clinical remission were 92.4% and 86.8%, respectively.

Conclusion

This study demonstrates that results from the CDAI correlated well with those from CDSD. Use of CDSD might permit simpler and patient-friendly CD activity assessment which can provide useful early-phase information of patients with CD in the long term clinical study.